The Framingham Heart Study is a project of Boston University & the National Heart, Lung, & Blood Institute.
The Framingham Heart Study is a project of Boston University & the National Heart, Lung, & Blood Institute.

FHS Guide for Researchers interested in Generation 3 Exam 4 Collaboration

Edition: February 24, 2020

Dear Framingham Heart Study Research Community,

The National Heart, Lung, and Blood Institute (NHLBI) has announced plans to fund a limited clinic exam cycle in the Generation 3 and Omni 2 Cohorts of the Framingham Heart Study (FHS).

The examination is expected to begin on or about January 2, 2022. The exam is intended in part to serve as a platform for additional, independently funded exam components via investigator-initiated grants or other independently funded projects to enrich the exam data collection with additional hypothesis-driven content. The research aims of such exam-related ancillary projects need not be limited to those within the mission of the NHLBI but must be consistent with and/or complement FHS study objectives.

Read more: NOT-HL-19-732

Regard the NHLBI Epidemiology Digital Forum: There is a statement in the Notice NOT-HL-19-732: “Further information about application submission timing is available on the NHLBI Epidemiology Digital Forum.”

Steps for Interested Researchers:

STEP 1: Review FHS proposal guidance online:

1) Guide for Investigators – II
2) For Researchers section
3) FHS Policies and Procedures section
4) Consider the projections and power calculations provided at the bottom of this page
5) Research Application FAQ (Update Coming Soon)

STEP 2: Apply for FHS Review Committees’ approval prior to your submission to any sponsor. Please apply for FHS approval online via the FHS Research Application

STEP 3: Apply for sponsorship. If you are interested in NIH funding, our Project Officers recommended the following R01 application dates posted below.

If you have questions and/or comments, please contact
Thank you,

Framingham Heart Study
Boston University School of Medicine

Projections & Power Calculations

Please see below for projections of the numbers of participants for the Gen 3 Exam 4 exam cycle (n=3374), breakdowns by cohort, sex, age group and race/ethnicity, and power calculations for various types of analyses.

  • Gen3 Based Exam 4 Projected Attendance (.docx file)
  • Gen3 Based Exam 4 Projected Attendance Corrected (.xlsx file)
  • Power for Gen3 Based Exam 4 (.docx file)
  • Power Calculations Exam 4 (.xlsx file)