The Framingham Heart Study is a project of Boston University & the National Heart, Lung, & Blood Institute.
The Framingham Heart Study is a project of Boston University & the National Heart, Lung, & Blood Institute.

Framingham Heart Study Bibliography – 2019

January

Alonso N, Estrada K, Albagha OME, Herrera L, Reppe S, Olstad OK, Gautvik KM, Ryan NM, Evans KL, Nielson CM, Hsu YH, Kiel DP, Markozannes G, Ntzani EE, Evangelou E, Feenstra B, Liu X, Melbye M, Masi L, Brandi ML, Riches P, Daroszewska A, Olmos JM, Valero C, Castillo J, Riancho JA, Husted LB, Langdahl BL, Brown MA, Duncan EL, Kaptoge S, Khaw KT, Usategui-Martin R, Del Pino-Montes J, Gonzalez-Sarmiento R, Lewis JR, Prince RL, D’Amelio P, Garcia-Giralt N, Nogues X, Mencej-Bedrac S, Marc J, Wolstein O, Eisman JA, Oei L, Medina-Gomez C, Schraut KE, Navarro P, Wilson JF, Davies G, Starr J, Deary I, Tanaka T, Ferrucci L, Gianfrancesco F, Gennari L, Lucas G, Elosua R, Uitterlinden AG, Rivadeneira F, Ralston SH. Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density. Ann Rheum Dis. 2018 Mar;77(3):378-85. Epub 2017/11/25. doi: 10.1136/annrheumdis-2017-212469. (PubMed ID Number: 29170203; PMCID: PMC5912156).

Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, Bradfield JP, Kreiner-Moller E, Huikari V, Metrustry S, Lunetta KL, Painter JN, Hottenga JJ, Allard C, Barton SJ, Espinosa A, Marsh JA, Potter C, Zhang G, Ang W, Berry DJ, Bouchard L, Das S, Hakonarson H, Heikkinen J, Helgeland O, Hocher B, Hofman A, Inskip HM, Jones SE, Kogevinas M, Lind PA, Marullo L, Medland SE, Murray A, Murray JC, Njolstad PR, Nohr EA, Reichetzeder C, Ring SM, Ruth KS, Santa-Marina L, Scholtens DM, Sebert S, Sengpiel V, Tuke MA, Vaudel M, Weedon MN, Willemsen G, Wood AR, Yaghootkar H, Muglia LJ, Bartels M, Relton CL, Pennell CE, Chatzi L, Estivill X, Holloway JW, Boomsma DI, Montgomery GW, Murabito JM, Spector TD, Power C, Jarvelin MR, Bisgaard H, Grant SFA, Sorensen TIA, Jaddoe VW, Jacobsson B, Melbye M, McCarthy MI, Hattersley AT, Hayes MG, Frayling TM, Hivert MF, Felix JF, Hypponen E, Lowe WL, Jr., Evans DM, Lawlor DA, Feenstra B, Freathy RM. Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Human molecular genetics. 2018 Feb 15;27(4):742-56. Epub 2018/01/09. doi: 10.1093/hmg/ddx429. (PubMed ID Number: 29309628; PMCID: PMC5886200).

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guethnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernandez M, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Munoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Volker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT, Jr., Debette S. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019 Jan 16. Epub 2019/01/18. doi: 10.1212/wnl.0000000000006851. (PubMed ID Number: 30651383; PMCID: PMC6369905).

Chen H, Huffman JE, Brody JA, Wang C, Lee S, Li Z, Gogarten SM, Sofer T, Bielak LF, Bis JC, Blangero J, Bowler RP, Cade BE, Cho MH, Correa A, Curran JE, de Vries PS, Glahn DC, Guo X, Johnson AD, Kardia S, Kooperberg C, Lewis JP, Liu X, Mathias RA, Mitchell BD, O’Connell JR, Peyser PA, Post WS, Reiner AP, Rich SS, Rotter JI, Silverman EK, Smith JA, Vasan RS, Wilson JG, Yanek LR, Redline S, Smith NL, Boerwinkle E, Borecki IB, Cupples LA, Laurie CC, Morrison AC, Rice KM, Lin X. Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies. Am J Hum Genet. 2019 Feb 7;104(2):260-74. Epub 2019/01/15. doi: 10.1016/j.ajhg.2018.12.012. (PubMed ID Number: 30639324).

de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, Li C, Feitosa MF, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Deng X, Dorajoo R, Lohman KK, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Evangelou E, Graff M, Alver M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Goel A, Hagemeijer Y, Harris SE, Hartwig FP, He M, Horimoto A, Hsu FC, Jackson AU, Kasturiratne A, Komulainen P, Kuhnel B, Laguzzi F, Lee JH, Luan J, Lyytikainen LP, Matoba N, Nolte IM, Pietzner M, Riaz M, Said MA, Scott RA, Sofer T, Stancakova A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Wang Y, Ware EB, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Amin N, Amini M, Arking DE, Aung T, Ballantyne C, Boerwinkle E, Broeckel U, Campbell A, Canouil M, Charumathi S, Chen YI, Connell JM, de Faire U, de Las Fuentes L, de Mutsert R, de Silva HJ, Ding J, Dominiczak AF, Duan Q, Eaton CB, Eppinga RN, Faul JD, Fisher V, Forrester T, Franco OH, Friedlander Y, Ghanbari M, Giulianini F, Grabe HJ, Grove ML, Gu CC, Harris TB, Heikkinen S, Heng CK, Hirata M, Hixson JE, Howard BV, Ikram MA, Jacobs DR, Jr., Johnson C, Jonas JB, Kammerer CM, Katsuya T, Khor CC, Kilpelainen TO, Koh WP, Koistinen HA, Kolcic I, Kooperberg C, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lemaitre RN, Li Y, Liang J, Liu J, Liu K, Loh M, Louie T, Magi R, Manichaikul AW, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Mosley TH, Jr., Mukamal KJ, Nalls MA, Nauck M, Nelson CP, Sotoodehnia N, O’Connell JR, Palmer ND, Pazoki R, Pedersen NL, Peters A, Peyser PA, Polasek O, Poulter N, Raffel LJ, Raitakari OT, Reiner AP, Rice TK, Rich SS, Robino A, Robinson JG, Rose LM, Rudan I, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Shi Y, Sidney S, Sims M, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tan N, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, van Heemst D, Vuckovic D, Waldenberger M, Wang L, Wang Y, Wang Z, Wei WB, Williams C, Wilson G, Sr., Wojczynski MK, Yao J, Yu B, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Deary IJ, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Kamatani Y, Kato N, Kooner JS, Laakso M, Leander K, Lehtimaki T, Magnusson PKE, Penninx B, Pereira AC, Rauramaa R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wang YX, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Zheng W, Elliott P, North KE, Bouchard C, Evans MK, Gudnason V, Liu CT, Liu Y, Psaty BM, Ridker PM, van Dam RM, Kardia SLR, Zhu X, Rotimi CN, Mook-Kanamori DO, Fornage M, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Liu J, Rotter JI, Gauderman WJ, Province MA, Munroe PB, Rice K, Chasman DI, Cupples LA, Rao DC, Morrison AC. Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American journal of epidemiology. 2019 Jan 29. Epub 2019/01/31. doi: 10.1093/aje/kwz005. (PubMed ID Number: 30698716).

de Vries PS, Sabater-Lleal M, Huffman JE, Marten J, Song C, Pankratz N, Bartz TM, de Haan HG, Delgado GE, Eicher JD, Martinez-Perez A, Ward-Caviness CK, Brody JA, Chen MH, de Maat MPM, Franberg M, Gill D, Kleber ME, Rivadeneira F, Soria JM, Tang W, Tofler GH, Uitterlinden AG, van Hylckama Vlieg A, Seshadri S, Boerwinkle E, Davies NM, Giese AK, Ikram MK, Kittner SJ, McKnight B, Psaty BM, Reiner AP, Sargurupremraj M, Taylor KD, Fornage M, Hamsten A, Marz W, Rosendaal FR, Souto JC, Dehghan A, Johnson AD, Morrison AC, O’Donnell CJ, Smith NL. A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology. Blood. 2019 Jan 14. Epub 2019/01/16. doi: 10.1182/blood-2018-05-849240. (PubMed ID Number: 30642921).

Fernandez-Sanles A, Sayols-Baixeras S, Curcio S, Subirana I, Marrugat J, Elosua R. DNA Methylation and Age-Independent Cardiovascular Risk, an Epigenome-Wide Approach: The REGICOR Study (REgistre GIroni del COR). Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):645-52. Epub 2018/01/13. doi: 10.1161/atvbaha.117.310340. (PubMed ID Number: 29326313; PMCID: PMC5823770).

He KY, Li X, Kelly TN, Liang J, Cade BE, Assimes TL, Becker LC, Beitelshees AL, Bress AP, Chang YC, Chen YI, de Vries PS, Fox ER, Franceschini N, Furniss A, Gao Y, Guo X, Haessler J, Hwang SJ, Irvin MR, Kalyani RR, Liu CT, Liu C, Martin LW, Montasser ME, Muntner PM, Mwasongwe S, Palmas W, Reiner AP, Shimbo D, Smith JA, Snively BM, Yanek LR, Boerwinkle E, Correa A, Cupples LA, He J, Kardia SLR, Kooperberg C, Mathias RA, Mitchell BD, Psaty BM, Vasan RS, Rao DC, Rich SS, Rotter JI, Wilson JG, Chakravarti A, Morrison AC, Levy D, Arnett DK, Redline S, Zhu X. Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data. Human genetics. 2019 Feb;138(2):199-210. Epub 2019/01/22. doi: 10.1007/s00439-019-01975-0. (PubMed ID Number: 30671673).

Keefe JA, Hwang SJ, Huan T, Mendelson M, Yao C, Courchesne P, Saleh MA, Madhur MS, Levy D. Evidence for a Causal Role of the SH2B3-beta2M Axis in Blood Pressure Regulation. Hypertension. 2019 Feb;73(2):497-503. Epub 2019/01/10. doi: 10.1161/hypertensionaha.118.12094. (PubMed ID Number: 30624993; PMCID: PMC6334659).

Kilpelainen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupovic H, Chasman DI, Manning A, Ntalla I, Aschard H, Brown MR, de Las Fuentes L, Franceschini N, Guo X, Vojinovic D, Aslibekyan S, Feitosa MF, Kho M, Musani SK, Richard M, Wang H, Wang Z, Bartz TM, Bielak LF, Campbell A, Dorajoo R, Fisher V, Hartwig FP, Horimoto A, Li C, Lohman KK, Marten J, Sim X, Smith AV, Tajuddin SM, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Evangelou E, Gao C, Graff M, Harris SE, He M, Hsu FC, Jackson AU, Zhao JH, Kraja AT, Kuhnel B, Laguzzi F, Lyytikainen LP, Nolte IM, Rauramaa R, Riaz M, Robino A, Rueedi R, Stringham HM, Takeuchi F, van der Most PJ, Varga TV, Verweij N, Ware EB, Wen W, Li X, Yanek LR, Amin N, Arnett DK, Boerwinkle E, Brumat M, Cade B, Canouil M, Chen YI, Concas MP, Connell J, de Mutsert R, de Silva HJ, de Vries PS, Demirkan A, Ding J, Eaton CB, Faul JD, Friedlander Y, Gabriel KP, Ghanbari M, Giulianini F, Gu CC, Gu D, Harris TB, He J, Heikkinen S, Heng CK, Hunt SC, Ikram MA, Jonas JB, Koh WP, Komulainen P, Krieger JE, Kritchevsky SB, Kutalik Z, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Leander K, Lemaitre RN, Lewis CE, Liang J, Liu J, Magi R, Manichaikul A, Meitinger T, Metspalu A, Milaneschi Y, Mohlke KL, Mosley TH, Jr., Murray AD, Nalls MA, Nang EK, Nelson CP, Nona S, Norris JM, Nwuba CV, O’Connell J, Palmer ND, Papanicolau GJ, Pazoki R, Pedersen NL, Peters A, Peyser PA, Polasek O, Porteous DJ, Poveda A, Raitakari OT, Rich SS, Risch N, Robinson JG, Rose LM, Rudan I, Schreiner PJ, Scott RA, Sidney SS, Sims M, Smith JA, Snieder H, Sofer T, Starr JM, Sternfeld B, Strauch K, Tang H, Taylor KD, Tsai MY, Tuomilehto J, Uitterlinden AG, van der Ende MY, van Heemst D, Voortman T, Waldenberger M, Wennberg P, Wilson G, Xiang YB, Yao J, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, de Faire U, Deary IJ, Elliott P, Esko T, Freedman BI, Froguel P, Gasparini P, Gieger C, Kato N, Laakso M, Lakka TA, Lehtimaki T, Magnusson PKE, Oldehinkel AJ, Penninx B, Samani NJ, Shu XO, van der Harst P, Van Vliet-Ostaptchouk JV, Vollenweider P, Wagenknecht LE, Wang YX, Wareham NJ, Weir DR, Wu T, Zheng W, Zhu X, Evans MK, Franks PW, Gudnason V, Hayward C, Horta BL, Kelly TN, Liu Y, North KE, Pereira AC, Ridker PM, Tai ES, van Dam RM, Fox ER, Kardia SLR, Liu CT, Mook-Kanamori DO, Province MA, Redline S, van Duijn CM, Rotter JI, Kooperberg CB, Gauderman WJ, Psaty BM, Rice K, Munroe PB, Fornage M, Cupples LA, Rotimi CN, Morrison AC, Rao DC, Loos RJF. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature communications. 2019 Jan 22;10(1):376. Epub 2019/01/24. doi: 10.1038/s41467-018-08008-w. (PubMed ID Number: 30670697; PMCID: PMC6342931).

Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF, Jr., Vasan RS, Benjamin EJ, Mittleman MA. Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study. Environmental research. 2018 Oct 28;171:36-43. Epub 2019/01/18. doi: 10.1016/j.envres.2018.10.027. (PubMed ID Number: 30654247).

Lindstrom S, Brody JA, Turman C, Germain M, Bartz TM, Smith EN, Chen MH, Puurunen M, Chasman D, Hassler J, Pankratz N, Basu S, Guan W, Gyorgy B, Ibrahim M, Empana JP, Olaso R, Jackson R, Braekkan SK, McKnight B, Deleuze JF, O’Donnell CJ, Jouven X, Frazer KA, Psaty BM, Wiggins KL, Taylor K, Reiner AP, Heckbert SR, Kooperberg C, Ridker P, Hansen JB, Tang W, Johnson AD, Morange PE, Tregouet DA, Kraft P, Smith NL, Kabrhel C. A large-scale exome array analysis of venous thromboembolism. Genetic epidemiology. 2019 Jan 19. Epub 2019/01/20. doi: 10.1002/gepi.22187. (PubMed ID Number: 30659681).

Mogil LS, Andaleon A, Badalamenti A, Dickinson SP, Guo X, Rotter JI, Johnson WC, Im HK, Liu Y, Wheeler HE. Genetic architecture of gene expression traits across diverse populations. PLoS Genet. 2018 Aug 10;14(8):e1007586. Epub 2018/08/11. doi: 10.1371/journal.pgen.1007586. (PubMed ID Number: 30096133; PMCID: PMC6105030).

Niiranen TJ, Kalesan B, Mitchell GF, Vasan RS. Relative Contributions of Pulse Pressure and Arterial Stiffness to Cardiovascular Disease. Hypertension. 2019 Mar;73(3):712-717. Epub 2019/01/22. doi: 10.1161/hypertensionaha.118.12289. (PubMed ID Number: 30661478; PMCID: PMC6374179).

Sofer T, Zheng X, Gogarten SM, Laurie CA, Grinde K, Shaffer JR, Shungin D, O’Connell JR, Durazo-Arvizo RA, Raffield L, Lange L, Musani S, Vasan RS, Cupples LA, Reiner AP, Laurie CC, Rice KM. A fully adjusted two-stage procedure for rank-normalization in genetic association studies. Genetic epidemiology. 2019 Jan 17. Epub 2019/01/18. doi: 10.1002/gepi.22188. (PubMed ID Number: 30653739).

Strand MP, Neogi T, Niu J, Felson DT, Haugen IK. Association Between Metabolic Syndrome and Radiographic Hand Osteoarthritis: Data From a Community-Based Longitudinal Cohort Study. Arthritis care & research. 2018 Mar;70(3):469-74. Epub 2017/05/26. doi: 10.1002/acr.23288. (PubMed ID Number: 28544753; PMCID: PMC5700863).

Tao Q, Ang TFA, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X, Massaro J, Au R, Qiu WQ. Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers. JAMA network open. 2018 Oct 5;1(6):e183597. Epub 2019/01/16. doi: 10.1001/jamanetworkopen.2018.3597. (PubMed ID Number: 30646251; PMCID: PMC6324596).

van den Heuvel ER, Vasan RS. Statistics in cardiovascular medicine: there is still gold in the old. Heart. 2018 July;104(14):1227. Epub 2018/06/28. doi: 10.1136/heartjnl-2018-313303. (PubMed ID Number: 29945950).

Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell chemical biology. 2019 Jan 17. Epub 2019/01/22. doi: 10.1016/j.chembiol.2018.11.015. (PubMed ID Number: 30661990).

Xu H, Cupples LA, Stokes A, Liu CT. Association of Obesity With Mortality Over 24 Years of Weight History: Findings From the Framingham Heart Study. JAMA network open. 2018 Nov 2;1(7):e184587. Epub 2019/01/16. doi: 10.1001/jamanetworkopen.2018.4587. (PubMed ID Number: 30646366; PMCID: PMC6324399).

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February

Conner SC, Benayoun L, Himali JJ, Adams SL, Yang Q, DeCarli C, Blusztajn JK, Beiser A, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer’s Disease Associates with Increased Odds for Brain Infarcts. J Alzheimers Dis. 2019 Feb 11. Epub 2019/02/19. doi: 10.3233/jad-180977. (PubMed ID Number: 30775993).

Dorr M, Hamburg NM, Muller C, Smith NL, Gustafsson S, Lehtimaki T, Teumer A, Zeller T, Li X, Lind L, Raitakari OT, Volker U, Blankenberg S, McKnight B, Morris AP, Kahonen M, Lemaitre RN, Wild PS, Nauck M, Volzke H, Munzel T, Mitchell GF, Psaty BM, Lindgren CM, Larson MG, Felix SB, Ingelsson E, Lyytikainen LP, Herrington D, Benjamin EJ, Schnabel RB. Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation. Circ Genom Precis Med. 2019 Feb;12(2):e002409. Epub 2019/02/20. doi: 10.1161/circgen.118.002409. (PubMed ID Number: 30779634).

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL, Fine RS, Guo X, Schurmann C, Lempradl A, Marouli E, Mahajan A, Winkler TW, Locke AE, Medina-Gomez C, Esko T, Vedantam S, Giri A, Lo KS, Alfred T, Mudgal P, Ng MCY, Heard-Costa NL, Feitosa MF, Manning AK, Willems SM, Sivapalaratnam S, Abecasis G, Alam DS, Allison M, Amouyel P, Arzumanyan Z, Balkau B, Bastarache L, Bergmann S, Bielak LF, Bluher M, Boehnke M, Boeing H, Boerwinkle E, Boger CA, Bork-Jensen J, Bottinger EP, Bowden DW, Brandslund I, Broer L, Burt AA, Butterworth AS, Caulfield MJ, Cesana G, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Collins FS, Cook JP, Cox AJ, Crosslin DS, Danesh J, de Bakker PIW, Denus S, Mutsert R, Dedoussis G, Demerath EW, Dennis JG, Denny JC, Angelantonio ED, Dorr M, Drenos F, Dube MP, Dunning AM, Easton DF, Elliott P, Evangelou E, Farmaki AE, Feng S, Ferrannini E, Ferrieres J, Florez JC, Fornage M, Fox CS, Franks PW, Friedrich N, Gan W, Gandin I, Gasparini P, Giedraitis V, Girotto G, Gorski M, Grallert H, Grarup N, Grove ML, Gustafsson S, Haessler J, Hansen T, Hattersley AT, Hayward C, Heid IM, Holmen OL, Hovingh GK, Howson JMM, Hu Y, Hung YJ, Hveem K, Ikram MA, Ingelsson E, Jackson AU, Jarvik GP, Jia Y, Jorgensen T, Jousilahti P, Justesen JM, Kahali B, Karaleftheri M, Kardia SLR, Karpe F, Kee F, Kitajima H, Komulainen P, Kooner JS, Kovacs P, Kramer BK, Kuulasmaa K, Kuusisto J, Laakso M, Lakka TA, Lamparter D, Lange LA, Langenberg C, Larson EB, Lee NR, Lee WJ, Lehtimaki T, Lewis CE, Li H, Li J, Li-Gao R, Lin LA, Lin X, Lind L, Lindstrom J, Linneberg A, Liu CT, Liu DJ, Luan J, Lyytikainen LP, MacGregor S, Magi R, Mannisto S, Marenne G, Marten J, Masca NGD, McCarthy MI, Meidtner K, Mihailov E, Moilanen L, Moitry M, Mook-Kanamori DO, Morgan A, Morris AP, Muller-Nurasyid M, Munroe PB, Narisu N, Nelson CP, Neville M, Ntalla I, O’Connell JR, Owen KR, Pedersen O, Peloso GM, Pennell CE, Perola M, Perry JA, Perry JRB, Pers TH, Ewing A, Polasek O, Raitakari OT, Rasheed A, Raulerson CK, Rauramaa R, Reilly DF, Reiner AP, Ridker PM, Rivas MA, Robertson NR, Robino A, Rudan I, Ruth KS, Saleheen D, Salomaa V, Samani NJ, Schreiner PJ, Schulze MB, Scott RA, Segura-Lepe M, Sim X, Slater AJ, Small KS, Smith BH, Smith JA, Southam L, Spector TD, Speliotes EK, Stefansson K, Steinthorsdottir V, Stirrups KE, Strauch K, Stringham HM, Stumvoll M, Sun L, Surendran P, Swart KMA, Tardif JC, Taylor KD, Teumer A, Thompson DJ, Thorleifsson G, Thorsteinsdottir U, Thuesen BH, Tonjes A, Torres M, Tsafantakis E, Tuomilehto J, Uitterlinden AG, Uusitupa M, van Duijn CM, Vanhala M, Varma R, Vermeulen SH, Vestergaard H, Vitart V, Vogt TF, Vuckovic D, Wagenknecht LE, Walker M, Wallentin L, Wang F, Wang CA, Wang S, Wareham NJ, Warren HR, Waterworth DM, Wessel J, White HD, Willer CJ, Wilson JG, Wood AR, Wu Y, Yaghootkar H, Yao J, Yerges-Armstrong LM, Young R, Zeggini E, Zhan X, Zhang W, Zhao JH, Zhao W, Zheng H, Zhou W, Zillikens MC, Rivadeneira F, Borecki IB, Pospisilik JA, Deloukas P, Frayling TM, Lettre G, Mohlke KL, Rotter JI, Kutalik Z, Hirschhorn JN, Cupples LA, Loos RJF, North KE, Lindgren CM. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nat Genet. 2019 Mar;51(3):452-69. Epub 2019/02/20. doi: 10.1038/s41588-018-0334-2. (PubMed ID Number: 30778226).

Karasik D, Zillikens MC, Hsu YH, Aghdassi A, Akesson K, Amin N, Barroso I, Bennett DA, Bertram L, Bochud M, Borecki IB, Broer L, Buchman AS, Byberg L, Campbell H, Campos-Obando N, Cauley JA, Cawthon PM, Chambers JC, Chen Z, Cho NH, Choi HJ, Chou WC, Cummings SR, de Groot L, De Jager PL, Demuth I, Diatchenko L, Econs MJ, Eiriksdottir G, Enneman AW, Eriksson J, Eriksson JG, Estrada K, Evans DS, Feitosa MF, Fu M, Gieger C, Grallert H, Gudnason V, Lenore LJ, Hayward C, Hofman A, Homuth G, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Johnson T, Biffar R, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpelainen TO, Klopp N, Kloth JSL, Koller DL, Kooner JS, Kraus WE, Kritchevsky S, Kutalik Z, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Lerch MM, Lewis JR, Lill C, Lind L, Lindgren C, Liu Y, Livshits G, Ljunggren O, Loos RJF, Lorentzon M, Luan J, Luben RN, Malkin I, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellstrom D, Michaelsson K, Mitchell BD, Morris AP, Mosekilde L, Nethander M, Newman AB, O’Connell JR, Oostra BA, Orwoll ES, Palotie A, Peacock M, Perola M, Peters A, Prince RL, Psaty BM, Raikkonen K, Ralston SH, Ripatti S, Rivadeneira F, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schipf S, Shin CS, Smith AV, Smith SB, Soranzo N, Spector TD, Stancakova A, Stefansson K, Steinhagen-Thiessen E, Stolk L, Streeten EA, Styrkarsdottir U, Swart KMA, Thompson P, Thomson CA, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Uitterlinden AG, van Duijn CM, van Schoor NM, Vandenput L, Vollenweider P, Volzke H, Wactawski-Wende J, Walker M, N JW, Waterworth D, Weedon MN, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Zhou Y, Nielson CM, Harris TB, Demissie S, Kiel DP, Ohlsson C. Disentangling the genetics of lean mass. The American journal of clinical nutrition. 2019 Feb 1;109(2):276-87. Epub 2019/02/06. doi: 10.1093/ajcn/nqy272. (PubMed ID Number: 30721968).

Ko D, Benson MD, Ngo D, Yang Q, Larson MG, Wang TJ, Trinquart L, McManus DD, Lubitz SA, Ellinor PT, Vasan RS, Gerszten RE, Benjamin EJ, Lin H. Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study. Journal of the American Heart Association. 2019 Mar 19;8(6):e010976. Epub 2019/03/08. doi: 10.1161/jaha.118.010976. (PubMed ID Number: 30841775).

Liu CT, Deng X, Fisher V, Heard-Costa N, Xu H, Zhou Y, Vasan RS, Cupples LA. Revisit Population-based and Family-based Genotype Imputation. Sci Rep. 2019 Feb 12;9(1):1800. Epub 2019/02/14. doi: 10.1038/s41598-018-38469-4. (PubMed ID Number: 30755687; PMCID: PMC63726600.

Liu J, Zhou H, Zhang Y, Huang Y, Fang W, Yang Y, Hong S, Chen G, Zhao S, Chen X, Zhang Z, Shen J, Xian W, Zhan J, Zhao Y, Hou X, Ma Y, Zhou T, Zhao H, Zhang L. Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study. Cancer medicine. 2019 Feb 11. Epub 2019/02/12. doi: 10.1002/cam4.2018. (PubMed ID Number: 30741477).

Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds L, Ghanbari M, Muka T, van Meurs J, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SL, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Murad SD, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Non-Alcoholic Fatty Liver Disease. Diabetes. 2019 Feb 22. Epub 2019/02/24. doi: 10.2337/db18-1193. (PubMed ID Number: 30796027).

McGrath ER, Himali JJ, Levy D, Conner SC, Pase MP, Abraham CR, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study. PLoS One. 2019 Mar 4;14(3):e0213321. Epub 2019/03/05. doi: 10.1371/journal.pone.0213321. (PubMed ID Number: 30830941; PMCID: PMC63989230.

McManus DD, Trinquart L, Benjamin EJ, Manders ES, Fusco K, Jung LS, Spartano NL, Kheterpal V, Nowak C, Sardana M, Murabito JM. Design and Preliminary Findings From a New Electronic Cohort Embedded in the Framingham Heart Study. Journal of medical Internet research. 2019 Mar 1;21(3):e12143. Epub 2019/03/02. doi: 10.2196/12143. (PubMed ID Number: 30821691).

Muller CP, Chu C, Qin L, Liu C, Xu B, Gao H, Ruggeri B, Hieber S, Schneider J, Jia T, Tay N, Akira S, Satoh T, Banaschewski T, Bokde ALW, Bromberg U, Buchel C, Quinlan EB, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Artiges E, Lemaitre H, Nees F, Papadopoulos Orfanos D, Paus T, Poustka L, Millenet S, Frohner JH, Smolka MN, Walter H, Whelan R, Bakalkin G, Liu Y, Desrivieres S, Elliott P, Eulenburg V, Levy D, Crews F, Schumann G. The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study. Cerebral cortex (New York, NY : 1991). 2019 Feb 4. Epub 2019/02/06. doi: 10.1093/cercor/bhy341. (PubMed ID Number: 30721969).

Pencina KM, Travison TG, Bhasin S, Li Z, Nigam N, Manning WJ, Vasan RS, Hoffmann U, O’Donnell CJ, Basaria S. Endogenous circulating testosterone and sex hormone-binding globulin levels and measures of myocardial structure and function: the Framingham Heart Study. Andrology. 2019 Feb 13. Epub 2019/02/15. doi: 10.1111/andr.12590. (PubMed ID Number: 30761772).

Peters R, Booth A, Rockwood K, Peters J, D’Este C, Anstey KJ. Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis. BMJ open. 2019 Jan 25;9(1):e022846. Epub 2019/02/21. doi: 10.1136/bmjopen-2018-022846. (PubMed ID Number: 30782689; PMCID: PMC63527720.

Spartano NL, Davis-Plourde KL, Himali JJ, Murabito JM, Vasan RS, Beiser AS, Seshadri S. Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study. Journal of diabetes research. 2019 Jan 9;2019:2718465. Epub 2019/02/08. doi: 10.1155/2019/2718465. (PubMed ID Number: 30729134; PMCID: PMC63431690.

Spartano NL, Lyass A, Larson MG, Tran T, Andersson C, Blease SJ, Esliger DW, Vasan RS, Murabito JM. Objective physical activity and physical performance in middle-aged and older adults. Experimental gerontology. 2019 May;119:203-11. Epub 2019/02/17. doi: 10.1016/j.exger.2019.02.003. (PubMed ID Number: 30771463).

Synn AJ, Zhang C, Washko GR, San Jose Estepar R, O’Connor GT, Li W, Mittleman MA, Rice MB. Cigarette Smoke Exposure and Radiographic Pulmonary Vascular Morphology in the Framingham Heart Study. Annals of the American Thoracic Society. 2019 Feb 4. Epub 2019/02/05. doi: 10.1513/AnnalsATS.201811-795OC. (PubMed ID Number: 30714821).

Tesarz J, Eich W, Baumeister D, Kohlmann T, D’Agostino R, Schuster AK. Widespread pain is a risk factor for cardiovascular mortality: results from the Framingham Heart Study. Eur Heart J. 2019 Mar 11. Epub 2019/03/13. doi: 10.1093/eurheartj/ehz111. (PubMed ID Number: 30859195).

Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, Haan MN, Seshadri S. Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts. PLoS One. 2019 Feb 15;14(2):e0212293. Epub 2019/02/16. doi: 10.1371/journal.pone.0212293. (PubMed ID Number: 30768625; PMCID: PMC63771880.

Yakushiji Y, Wilson D, Ambler G, Charidimou A, Beiser A, van Buchem MA, DeCarli C, Ding D, Gudnason V, Hara H, Imaizumi T, Kohara K, Kwon HM, Launer LJ, Mok V, Phan T, Preis SR, Romero JR, Seshadri S, Srikanth V, Takashima Y, Tsushima Y, Wang Z, Wolf PA, Xiong Y, Yamaguchi S, Werring DJ. Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis. Neurology. 2019 Mar 5;92(10):e1086-e97. Epub 2019/02/03. doi: 10.1212/wnl.0000000000007039. (PubMed ID Number: 30709966).

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March

Atem FD, Matsouaka RA, Zimmern VE. Cox regression model with randomly censored covariates. Biom J. 2019 March 25. Epub 2019/03/26. doi: 10.1002/bimj.201800275. (PubMed ID Number: 30908720).

Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI, Lim E, Deng X, Guo X, Liu J, Lu Y, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, Li C, Feitosa MF, Richard MA, Noordam R, Baker J, Chen G, Aschard H, Bartz TM, Ding J, Dorajoo R, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Zhao W, Graff M, Alver M, Boissel M, Chai JF, Chen X, Divers J, Evangelou E, Gao C, Goel A, Hagemeijer Y, Harris SE, Hartwig FP, He M, Horimoto A, Hsu FC, Hung YJ, Jackson AU, Kasturiratne A, Komulainen P, Kuhnel B, Leander K, Lin KH, Luan J, Lyytikainen LP, Matoba N, Nolte IM, Pietzner M, Prins B, Riaz M, Robino A, Said MA, Schupf N, Scott RA, Sofer T, Stancakova A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Wang TD, Wang Y, Ware EB, Wen W, Xiang YB, Yanek LR, Zhang W, Zhao JH, Adeyemo A, Afaq S, Amin N, Amini M, Arking DE, Arzumanyan Z, Aung T, Ballantyne C, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Broeckel U, Brown M, Cade BE, Campbell A, Canouil M, Charumathi S, Chen YI, Christensen K, Concas MP, Connell JM, de Las Fuentes L, de Silva HJ, de Vries PS, Doumatey A, Duan Q, Eaton CB, Eppinga RN, Faul JD, Floyd JS, Forouhi NG, Forrester T, Friedlander Y, Gandin I, Gao H, Ghanbari M, Gharib SA, Gigante B, Giulianini F, Grabe HJ, Gu CC, Harris TB, Heikkinen S, Heng CK, Hirata M, Hixson JE, Ikram MA, Jia Y, Joehanes R, Johnson C, Jonas JB, Justice AE, Katsuya T, Khor CC, Kilpelainen TO, Koh WP, Kolcic I, Kooperberg C, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Liang J, Lin S, Liu CT, Liu J, Liu K, Loh M, Lohman KK, Louie T, Luzzi A, Magi R, Mahajan A, Manichaikul AW, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Momozawa Y, Morris AP, Murray AD, Nalls MA, Nauck M, Nelson CP, North KE, O’Connell JR, Palmer ND, Papanicolau GJ, Pedersen NL, Peters A, Peyser PA, Polasek O, Poulter N, Raitakari OT, Reiner AP, Renstrom F, Rice TK, Rich SS, Robinson JG, Rose LM, Rosendaal FR, Rudan I, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Shi Y, Sidney S, Sims M, Smith JA, Snieder H, Starr JM, Strauch K, Stringham HM, Tan NYQ, Tang H, Taylor KD, Teo YY, Tham YC, Tiemeier H, Turner ST, Uitterlinden AG, van Heemst D, Waldenberger M, Wang H, Wang L, Wang L, Wei WB, Williams CA, Wilson G, Sr., Wojczynski MK, Yao J, Young K, Yu C, Yuan JM, Zhou J, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Cooper RS, de Faire U, Deary IJ, Elliott P, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Juang JJ, Kamatani Y, Kammerer CM, Kato N, Kooner JS, Laakso M, Laurie CC, Lee IT, Lehtimaki T, Magnusson PKE, Oldehinkel AJ, Penninx B, Pereira AC, Rauramaa R, Redline S, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wang JS, Wang YX, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zeggini E, Zheng W, Bouchard C, Evans MK, Gudnason V, Kardia SLR, Liu Y, Psaty BM, Ridker PM, van Dam RM, Mook-Kanamori DO, Fornage M, Province MA, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Franceschini N, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Rice K, Munroe PB, Morrison AC, Rao DC, Rotimi CN, Cupples LA. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019 April;51(4):636-48. Epub 2019/03/31. doi: 10.1038/s41588-019-0378-y. (PubMed ID Number: 30926973; PMCID: PMC6467258).

Cawthon PM, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA, Magaziner JM, Newman AB, Brown T, Kiel DP, Cummings SR, Shardel M, Guralnik J, Woodhouse LJ, Pahor M, Binder E, D’Agostino RB, Xue QL, Orwoll E, Landi F, Orwig D, Schaap L, Latham NN, Hirani V, Kwok T, Pereira S, Rooks D, Kashiwa M, Torres-Gonzalez M, Menetski JP, Correa-De-Araujo R, Bhasin S. Establishing the Link Between Lean Mass and Grip Strength Cut-points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference. J Gerontol A Biol Sci Med Sci. 2019 March 14. Epub 2019/03/15. doi: 10.1093/gerona/glz081. (PubMed ID Number: 30869772).

Echouffo-Tcheugui JB, Short MI, Xanthakis V, Field P, Sponholtz TR, Larson MG, Vasan RS. Natural History of Obesity Subphenotypes: Dynamic Changes Over Two Decades and Prognosis in the Framingham Heart Study. J Clin Endocrinol Metab. 2019 March 1;104(3):738-52. Epub 2018/10/20. doi: 10.1210/jc.2018-01321. (PubMed ID Number: 30339231; PMCID: PMC6349002).

Hennein R, Liu C, McKeown NM, Hoffmann U, Long MT, Levy D, Ma J. Increased Diet Quality is Associated with Long-Term Reduction of Abdominal and Pericardial Fat. Obesity (Silver Spring). 2019 April;27(4):670-7. Epub 2019/03/03. doi: 10.1002/oby.22427. (PubMed ID Number: 30825267; PMCID: PMC6430652).

Hruby A, Jacques PF. Dietary Protein and Changes in Biomarkers of Inflammation and Oxidative Stress in the Framingham Heart Study Offspring Cohort. Curr Dev Nutr. 2019 March 28;3(5):nzz019. Epub 2019/05/01. doi: 10.1093/cdn/nzz019. (PubMed ID Number: 31037277; PMCID: PMC6483052).

Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M, Lorentzon M, McGuigan F, Medina-Gomez C, Mitchell B, Newman A, Nielson C, Ohlsson C, Peacock M, Reppe S, Richards JB, Robbins J, Sigurdsson G, Spector TD, Stefansson K, Streeten E, Styrkarsdottir U, Tobias J, Trajanoska K, Uitterlinden A, Vandenput L, Wilson SG, Yerges-Armstrong L, Young M, Zillikens C, Rivadeneira F, Kiel DP, Karasik D. Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry. J Bone Miner Res. 2019 March 19:e3698. Epub 2019/03/20. doi: 10.1002/jbmr.3698. (PubMed ID Number: 30888730).

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, 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D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, M COD, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing. Nat Genet. 2019 March;51(3):414-30. Epub 2019/03/02. doi: 10.1038/s41588-019-0358-2. (PubMed ID Number: 30820047; PMCID: PMC6463297).

Lieb W, Song RJ, Xanthakis V, Vasan RS. Association of Circulating Tissue Inhibitor of Metalloproteinases-1 and Procollagen Type III Aminoterminal Peptide Levels With Incident Heart Failure and Chronic Kidney Disease. J Am Heart Assoc. 2019 April 2;8(7):e011426. Epub 2019/03/21. doi: 10.1161/jaha.118.011426. (PubMed ID Number: 30890055).

Mishra A, Chauhan G, Violleau MH, Vojinovic D, Jian X, Bis JC, Li S, Saba Y, Grenier-Boley B, Yang Q, Bartz TM, Hofer E, Soumare A, Peng F, Duperron MG, Foglio M, Mosley TH, Schmidt R, Psaty BM, Launer LJ, Boerwinkle E, Zhu Y, Mazoyer B, Lathrop M, Bellenguez C, Van Duijn CM, Ikram MA, Schmidt H, Longstreth WT, Fornage M, Seshadri S, Joutel A, Tzourio C, Debette S. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. Brain. 2019 April;142(4):1009-23. Epub 2019/03/13. doi: 10.1093/brain/awz024. (PubMed ID Number: 30859180; PMCID: PMC6439324).

Niiranen TJ, Kalesan B, Mitchell GF, Vasan RS. Relative Contributions of Pulse Pressure and Arterial Stiffness to Cardiovascular Disease. Hypertension. 2019 March;73(3):712-7. Epub 2019/01/22. doi: 10.1161/hypertensionaha.118.12289. (PubMed ID Number: 30661478; PMCID: PMC6374179).

Pase MP, Beiser AS, Himali JJ, Satizabal CL, Aparicio HJ, DeCarli C, Chene G, Dufouil C, Seshadri S. Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes. JAMA Neurol. 2019 March 4. Epub 2019/03/05. doi: 10.1001/jamaneurol.2018.4666. (PubMed ID Number: 30830207).

Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O’Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Bosse Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019 March;51(3):494-505. Epub 2019/02/26. doi: 10.1038/s41588-018-0342-2. (PubMed ID Number: 30804561).

Wang L, Perez J, Heard-Costa N, Chu AY, Joehanes R, Munson PJ, Levy D, Fox CS, Cupples LA, Liu CT. Integrating genetic, transcriptional, and biological information provides insights into obesity. Int J Obes (Lond). 2019 March;43(3):457-67. Epub 2018/09/21. doi: 10.1038/s41366-018-0190-2. (PubMed ID Number: 30232418; PMCID: PMC6405310).

Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell Chem Biol. 2019 March 21;26(3):433-42.e4. Epub 2019/01/22. doi: 10.1016/j.chembiol.2018.11.015. (PubMed ID Number: 30661990).

Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, Smith AV, Sun F, Terzikhan N, Markunas CA, Patchen BK, Schu M, Beydoun MA, Brusselle GG, Eiriksdottir G, Zhou X, Wood AC, Graff M, Harris TB, Ikram MA, Jacobs DR, Jr., Launer LJ, Lemaitre RN, O’Connor GT, Oelsner EC, Psaty BM, Vasan RS, Rohde RR, Rich SS, Rotter JI, Seshadri S, Smith LJ, Tiemeier H, Tsai MY, Uitterlinden AG, Voruganti VS, Xu H, Zilhao NR, Fornage M, Zillikens MC, London SJ, Barr RG, Dupuis J, Gharib SA, Gudnason V, Lahousse L, North KE, Steffen LM, Cassano PA, Hancock DB. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Am J Respir Crit Care Med. 2019 March 1;199(5):631-42. Epub 2018/09/11. doi: 10.1164/rccm.201802-0304OC. (PubMed ID Number: 30199657; PMCID: PMC6396866).

Zhao Y, Blencowe M, Shi X, Shu L, Levian C, Ahn IS, Kim SK, Huan T, Levy D, Yang X. Integrative Genomics Analysis Unravels Tissue-Specific Pathways, Networks, and Key Regulators of Blood Pressure Regulation. Front Cardiovasc Med. 2019;6:21. Epub 2019/04/02. doi: 10.3389/fcvm.2019 March 12.00021. (PubMed ID Number: 30931314; PMCID: PMC6423920).

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April

Fretts AM, Imamura F, Marklund M, Micha R, Wu JHY, Murphy RA, Chien KL, McKnight B, Tintle N, Forouhi NG, Qureshi WT, Virtanen JK, Wong K, Wood AC, Lankinen M, Rajaobelina K, Harris TB, Djousse L, Harris B, Wareham NJ, Steffen LM, Laakso M, Veenstra J, Samieri C, Brouwer IA, Yu CI, Koulman A, Steffen BT, Helmer C, Sotoodehnia N, Siscovick D, Gudnason V, Wagenknecht L, Voutilainen S, Tsai MY, Uusitupa M, Kalsbeek A, Berr C, Mozaffarian D, Lemaitre RN. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies. Am J Clin Nutr. 2019;109(4):1216-23. Epub 2019/04/16. doi: 10.1093/ajcn/nqz005. (PubMed ID Number: 30982858; PMCID: PMC6500926).

Koupenova M, Corkrey HA, Vitseva O, Manni G, Pang CJ, Clancy L, Yao C, Rade J, Levy D, Wang JP, Finberg RW, Kurt-Jones EA, Freedman JE. The role of platelets in mediating a response to human influenza infection. Nat Commun. 2019;10(1):1780. Epub 2019/04/18. doi: 10.1038/s41467-019-09607-x. (PubMed ID Number: 30992428; PMCID: PMC6467905).

Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds LM, Ghanbari M, Muka T, van Meurs JBJ, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SLR, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Darwish Murad S, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease. Diabetes. 2019;68(5):1073-83. Epub 2019/04/03. doi: 10.2337/db18-1193. (PubMed ID Number: 30936141; PMCID: PMC6477898).

Spartano NL, Davis-Plourde KL, Himali JJ, Andersson C, Pase MP, Maillard P, DeCarli C, Murabito JM, Beiser AS, Vasan RS, Seshadri S. Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study. JAMA Netw Open. 2019;2(4):e192745. Epub 2019/04/20. doi: 10.1001/jamanetworkopen.2019.2745. (PubMed ID Number: 31002329; PMCID: PMC6481600).

Sponholtz TR, van den Heuvel ER, Xanthakis V, Vasan RS. Association of Variability in Body Mass Index and Metabolic Health With Cardiometabolic Disease Risk. J Am Heart Assoc. 2019;8(7):e010793. Epub 2019/04/27. doi: 10.1161/jaha.118.010793. (PubMed ID Number: 31025893; PMCID: PMC6509716).

Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Kilpelainen TO, Richard MA, Aslibekyan S, Bartz TM, Dorajoo R, Li C, Liu Y, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, He M, Horimoto A, Hsu FC, Jackson AU, Kammerer CM, Kasturiratne A, Komulainen P, Kuhnel B, Leander K, Lee WJ, Lin KH, Luan J, Lyytikainen LP, McKenzie CA, Nelson CP, Noordam R, Scott RA, Sheu WHH, Stancakova A, Takeuchi F, van der Most PJ, Varga TV, Waken RJ, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking DE, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cade B, Campbell A, Canouil M, Chakravarti A, Cocca M, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Dorr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Forouhi NG, Franco OH, Friedlander Y, Gao H, Gigante B, Gu CC, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hofman A, Howard BV, Hunt SC, Irvin MR, Jia Y, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Kooperberg CB, Krieger JE, Kubo M, Kutalik Z, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lee JH, Lehne B, Levy D, Lewis CE, Li Y, Lim SH, Liu CT, Liu J, Liu J, Liu Y, Loh M, Lohman KK, Louie T, Magi R, Matsuda K, Meitinger T, Metspalu A, Milani L, Momozawa Y, Mosley TH, Jr., Nalls MA, Nasri U, O’Connell JR, Ogunniyi A, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Porteous D, Raitakari OT, Renstrom F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Sims M, Sitlani CM, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Wilson G, Wojczynski MK, Xiang YB, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, Weir DR, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimaki T, Liang KW, Magnusson PKE, Oldehinkel AJ, Pereira AC, Perls T, Rauramaa R, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Wickremasinghe AR, Wu T, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Hixson J, Kardia SLR, Kritchevsky SB, Psaty BM, van Dam RM, Arnett DK, Mook-Kanamori DO, Fornage M, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotimi CN, Bierut LJ, Zhu X, Cupples LA, Province MA, Rotter JI, Franks PW, Rice K, Elliott P, Caulfield MJ, Gauderman WJ, Munroe PB, Rao DC, Morrison AC. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019. Epub 2019/05/28. doi: 10.1093/hmg/ddz070. (PubMed ID Number: 31127295).

Wilechansky RM, Pedley A, Massaro JM, Hoffmann U, Benjamin EJ, Long MT. Relations of liver fat with prevalent and incident chronic kidney disease in the Framingham Heart Study: A secondary analysis. Liver Int. 2019. Epub 2019/04/30. doi: 10.1111/liv.14125. (PubMed ID Number: 31033142).

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May

Andersson C, Johnson AD, Benjamin EJ, Levy D, Vasan RS. 70-year legacy of the Framingham Heart Study. Nat Rev Cardiol. May 2019. Epub 2019/05/09. doi: 10.1038/s41569-019-0202-5. (PubMed ID Number: 31065045).

Aparicio HJ, Himali JJ, Satizabal CL, Pase MP, Romero JR, Kase CS, Beiser AS, Seshadri S. Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study. Stroke. June 2019;50(6):1558-60. Epub 2019/05/16. doi: 10.1161/strokeaha.119.025171. (PubMed ID Number: 31084341; PMCID: PMC6538454).

Carter AR, Gill D, Davies NM, Taylor AE, Tillmann T, Vaucher J, Wootton RE, Munafo MR, Hemani G, Malik R, Seshadri S, Woo D, Burgess S, Davey Smith G, Holmes MV, Tzoulaki I, Howe LD, Dehghan A. Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study. BMJ. May 2019;365:l1855. Epub 2019/05/28. doi: 10.1136/bmj.l1855. (PubMed ID Number: 31122926; PMCID: PMC6529852).

Conner SC, Sullivan LM, Benjamin EJ, LaValley MP, Galea S, Trinquart L. Adjusted restricted mean survival times in observational studies. Stat Med. May 2019. Epub 2019/05/24. doi: 10.1002/sim.8206. (PubMed ID Number: 31119770).

Duncan MS, Vasan RS, Xanthakis V. Trajectories of Blood Lipid Concentrations Over the Adult Life Course and Risk of Cardiovascular Disease and All-Cause Mortality: Observations From the Framingham Study Over 35 Years. J Am Heart Assoc. June 2019;8(11):e011433. Epub 2019/05/30. doi: 10.1161/jaha.118.011433. (PubMed ID Number: 31137992).

Ebbert MTW, Jensen TD, Jansen-West K, Sens JP, Reddy JS, Ridge PG, Kauwe JSK, Belzil V, Pregent L, Carrasquillo MM, Keene D, Larson E, Crane P, Asmann YW, Ertekin-Taner N, Younkin SG, Ross OA, Rademakers R, Petrucelli L, Fryer JD. Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight. Genome Biol. May 2019;20(1):97. Epub 2019/05/21. doi: 10.1186/s13059-019-1707-2. (PubMed ID Number: 31104630; PMCID: PMC6526621).

Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Cordova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, Garcia-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jorgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martinez-Hernandez A, Matsuo K, Mayer-Davis E, Mendoza-Caamal E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O’Dushlaine C, Payne AJ, Pihoker C, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberon X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O’Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusie-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. June 2019;570(7759):71-6. Epub 2019/05/24. doi: 10.1038/s41586-019-1231-2. (PubMed ID Number: 31118516).

Foldyna B, Eslami P, Scholtz JE, Baltrusaitis K, Lu MT, Massaro JM, D’Agostino RB, Sr., Ferencik M, Aerts H, O’Donnell CJ, Hoffmann U. Density and morphology of coronary artery calcium for the prediction of cardiovascular events: insights from the Framingham Heart Study. Eur Radiol. May 2019. Epub 2019/05/03. doi: 10.1007/s00330-019-06223-7. (PubMed ID Number: 31049733).

Ma Y, Jun GR, Chung J, Zhang X, Kunkle BW, Naj AC, White CC, Bennett DA, De Jager PL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Farrer LA, Lunetta KL. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. Aging Cell. May 2019:e12964. Epub 2019/05/31. doi: 10.1111/acel.12964. (PubMed ID Number: 31144443).

Marklund M, Wu JHY, Imamura F, Del Gobbo LC, Fretts A, de Goede J, Shi P, Tintle N, Wennberg M, Aslibekyan S, Chen TA, de Oliveira Otto MC, Hirakawa Y, Eriksen HH, Kroger J, Laguzzi F, Lankinen M, Murphy RA, Prem K, Samieri C, Virtanen J, Wood AC, Wong K, Yang WS, Zhou X, Baylin A, Boer JMA, Brouwer IA, Campos H, Chaves PHM, Chien KL, de Faire U, Djousse L, Eiriksdottir G, El-Abbadi N, Forouhi NG, Michael Gaziano J, Geleijnse JM, Gigante B, Giles G, Guallar E, Gudnason V, Harris T, Harris WS, Helmer C, Hellenius ML, Hodge A, Hu FB, Jacques PF, Jansson JH, Kalsbeek A, Khaw KT, Koh WP, Laakso M, Leander K, Lin HJ, Lind L, Luben R, Luo J, McKnight B, Mursu J, Ninomiya T, Overvad K, Psaty BM, Rimm E, Schulze MB, Siscovick D, Skjelbo Nielsen M, Smith AV, Steffen BT, Steffen L, Sun Q, Sundstrom J, Tsai MY, Tunstall-Pedoe H, Uusitupa MIJ, van Dam RM, Veenstra J, Monique Verschuren WM, Wareham N, Willett W, Woodward M, Yuan JM, Micha R, Lemaitre RN, Mozaffarian D, Riserus U. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality. Circulation. May 2019;139(21):2422-36. Epub 2019/04/12. doi: 10.1161/circulationaha.118.038908. (PubMed ID Number: 30971107; PMCID: PMC6582360).

Saylor KW, Ekunwe L, Antoine-LaVigne D, Sellers DE, McGraw S, Levy D, Splansky GL, Joffe S. Attitudes Toward Genetics and Genetic Testing Among Participants in the Jackson and Framingham Heart Studies. J Empir Res Hum Res Ethics. July 2019;14(3):262-73. Epub 2019/05/10. doi: 10.1177/1556264619844851. (PubMed ID Number: 31068049; PMCID: PMC6565476).

Ward-Caviness CK, de Vries PS, Wiggins KL, Huffman JE, Yanek LR, Bielak LF, Giulianini F, Guo X, Kleber ME, Kacprowski T, Gross S, Petersman A, Davey Smith G, Hartwig FP, Bowden J, Hemani G, Muller-Nuraysid M, Strauch K, Koenig W, Waldenberger M, Meitinger T, Pankratz N, Boerwinkle E, Tang W, Fu YP, Johnson AD, Song C, de Maat MPM, Uitterlinden AG, Franco OH, Brody JA, McKnight B, Chen YI, Psaty BM, Mathias RA, Becker DM, Peyser PA, Smith JA, Bielinski SJ, Ridker PM, Taylor KD, Yao J, Tracy R, Delgado G, Trompet S, Sattar N, Jukema JW, Becker LC, Kardia SLR, Rotter JI, Marz W, Dorr M, Chasman DI, Dehghan A, O’Donnell CJ, Smith NL, Peters A, Morrison AC. Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease. PLoS ONE. May 2019;14(5):e0216222. Epub 2019/05/11. doi: 10.1371/journal.pone.0216222. (PubMed ID Number: 31075152).

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, Nutile T, Fuchsberger C, Marten J, Cocca M, Ghasemi S, Xu Y, Horn K, Noce D, van der Most PJ, Sedaghat S, Yu Z, Akiyama M, Afaq S, Ahluwalia TS, Almgren P, Amin N, Arnlov J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boehnke M, Boerwinkle E, Boissel M, Bottinger EP, Boutin TS, Brenner H, Brumat M, Burkhardt R, Butterworth AS, Campana E, Campbell A, Campbell H, Canouil M, Carroll RJ, Catamo E, Chambers JC, Chee ML, Chee ML, Chen X, Cheng CY, Cheng Y, Christensen K, Cifkova R, Ciullo M, Concas MP, Cook JP, Coresh J, Corre T, Sala CF, Cusi D, Danesh J, Daw EW, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Delgado G, Demirkan A, Di Angelantonio E, Dittrich K, Divers J, Dorajoo R, Eckardt KU, Ehret G, Elliott P, Endlich K, Evans MK, Felix JF, Foo VHX, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Friedlander Y, Froguel P, Gansevoort RT, Gao H, Gasparini P, Gaziano JM, Giedraitis V, Gieger C, Girotto G, Giulianini F, Gogele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hartman CA, Hayward C, Hellwege JN, Heng CK, Hicks AA, Hofer E, Huang W, Hutri-Kahonen N, Hwang SJ, Ikram MA, Indridason OS, Ingelsson E, Ising M, Jaddoe VWV, Jakobsdottir J, Jonas JB, Joshi PK, Josyula NS, Jung B, Kahonen M, Kamatani Y, Kammerer CM, Kanai M, Kastarinen M, Kerr SM, Khor CC, Kiess W, Kleber ME, Koenig W, Kooner JS, Korner A, Kovacs P, Kraja AT, Krajcoviechova A, Kramer H, Kramer BK, Kronenberg F, Kubo M, Kuhnel B, Kuokkanen M, Kuusisto J, La Bianca M, Laakso M, Lange LA, Langefeld CD, Lee JJ, Lehne B, Lehtimaki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Liu J, Loeffler M, Loos RJF, Lucae S, Lukas MA, Lyytikainen LP, Magi R, Magnusson PKE, Mahajan A, Martin NG, Martins J, Marz W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Melander O, Metspalu A, Mikaelsdottir EK, Milaneschi Y, Miliku K, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O’Connell J, O’Donoghue ML, Olafsson I, Oldehinkel AJ, Orho-Melander M, Ouwehand WH, Padmanabhan S, Palmer ND, Palsson R, Penninx B, Perls T, Perola M, Pirastu M, Pirastu N, Pistis G, Podgornaia AI, Polasek O, Ponte B, Porteous DJ, Poulain T, Pramstaller PP, Preuss MH, Prins BP, Province MA, Rabelink TJ, Raffield LM, Raitakari OT, Reilly DF, Rettig R, Rheinberger M, Rice KM, Ridker PM, Rivadeneira F, Rizzi F, Roberts DJ, Robino A, Rossing P, Rudan I, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Sabanayagam C, Salomaa V, Salvi E, Saum KU, Schmidt H, Schmidt R, Schottker B, Schulz CA, Schupf N, Shaffer CM, Shi Y, Smith AV, Smith BH, Soranzo N, Spracklen CN, Strauch K, Stringham HM, Stumvoll M, Svensson PO, Szymczak S, Tai ES, Tajuddin SM, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorleifsson G, Toniolo D, Tonjes A, Tremblay J, Tzoulaki I, Uitterlinden AG, Vaccargiu S, van Dam RM, van der Harst P, van Duijn CM, Velez Edward DR, Verweij N, Vogelezang S, Volker U, Vollenweider P, Waeber G, Waldenberger M, Wallentin L, Wang YX, Wang C, Waterworth DM, Bin Wei W, White H, Whitfield JB, Wild SH, Wilson JF, Wojczynski MK, Wong C, Wong TY, Xu L, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang W, Zonderman AB, Rotter JI, Bochud M, Psaty BM, Vitart V, Wilson JG, Dehghan A, Parsa A, Chasman DI, Ho K, Morris AP, Devuyst O, Akilesh S, Pendergrass SA, Sim X, Boger CA, Okada Y, Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Kottgen A, Pattaro C. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet. June 2019;51(6):957-72. Epub 2019/06/04. doi: 10.1038/s41588-019-0407-x. (PubMed ID Number: 31152163).

Yang Y, Wu L, Shu XO, Cai Q, Shu X, Li B, Guo X, Ye F, Michailidou K, Bolla MK, Wang Q, Dennis J, Andrulis IL, Brenner H, Chenevix-Trench G, Campa D, Castelao JE, Gago-Dominguez M, Dork T, Hollestelle A, Lophatananon A, Muir K, Neuhausen SL, Olsson H, Sandler DP, Simard J, Kraft P, Pharoah PDP, Easton DF, Zheng W, Long J. Genetically predicted levels of DNA methylation biomarkers and breast cancer risk: data from 228,951 women of European descent. J Natl Cancer Inst. May 2019. Epub 2019/05/31. doi: 10.1093/jnci/djz109. (PubMed ID Number: 31143935).

Yu M, Georges A, Tucker NR, Kyryachenko S, Toomer K, Schott JJ, Delling FN, Fernandez-Friera L, Solis J, Ellinor PT, Levine RA, Slaugenhaupt SA, Hagege AA, Dina C, Jeunemaitre X, Milan DJ, Norris RA, Bouatia-Naji N. Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. May 2019;12(5):e002497. Epub 2019/05/22. doi: 10.1161/circgen.119.002497. (PubMed ID Number: 31112420; PMCID: PMC6532425).

Zeng B, Lloyd-Jones LR, Montgomery GW, Metspalu A, Esko T, Franke L, Vosa U, Claringbould A, Brigham KL, Quyyumi AA, Idaghdour Y, Yang J, Visscher PM, Powell JE, Gibson G. Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation. Genetics. May 2019. Epub 2019/05/28. doi: 10.1534/genetics.119.302091. (PubMed ID Number: 31123039).

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June

Ang TFA, An N, Ding H, Devine S, Auerbach SH, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R, Lin H. Using data science to diagnose and characterize heterogeneity of Alzheimer’s disease. Alzheimers Dement (N Y). 2019 June;5:264-71. Epub 2019/07/16. doi: 10.1016/j.trci.2019.05.002. (PubMed ID Number: 31304232; PMCID: PMC6603309).

Bae H, Lunetta KL, Murabito JM, Andersen SL, Schupf N, Perls T, Sebastiani P. Genetic associations with age of menopause in familial longevity. Menopause. 2019 June. Epub 2019/06/13. doi: 10.1097/gme.0000000000001367. (PubMed ID Number: 31188284).

Chen VL, Wright AP, Halligan B, Chen Y, Du X, Handelman SK, Long MT, Kiel DP, Speliotes EK. Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis. Hepatol Commun. 2019 June;3(8):1073-84. Epub 2019/08/08. doi: 10.1002/hep4.1391. (PubMed ID Number: 31388628; PMCID: PMC6671828).

Fleck D, Phu L, Verschueren E, Hinkle T, Reichelt M, Bhangale T, Haley B, Wang Y, Graham R, Kirkpatrick DS, Sheng M, Bingol B. PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer’s Disease. J Neurosci. 2019 June;39(24):4636-56. Epub 2019/04/06. doi: 10.1523/jneurosci.0116-19.2019. (PubMed ID Number: 30948477; PMCID: PMC6561697).

Ikezaki H, Fisher VA, Lim E, Ai M, Liu CT, Adrienne Cupples L, Nakajima K, Asztalos BF, Furusyo N, Schaefer EJ. Direct Versus Calculated LDL Cholesterol and C-Reactive Protein in Cardiovascular Disease Risk Assessment in the Framingham Offspring Study. Clin Chem. 2019 September;65(9):1102-14. Epub 2019/06/27. doi: 10.1373/clinchem.2019.304600. (PubMed ID Number: 31239251).

Kaess BM, Andersson C, Duncan MS, Larson MG, Aasbjerg K, Gislason GH, Torp-Pedersen C, Vasan RS. Familial Clustering of Cardiac Conduction Defects and Pacemaker Insertion. Circ Arrhythm Electrophysiol. 2019 July;12(7):e007150. Epub 2019/06/21. doi: 10.1161/circep.119.007150. (PubMed ID Number: 31216886; PMCID: PMC6588168).

Liu J, Carnero-Montoro E, van Dongen J, Lent S, Nedeljkovic I, Ligthart S, Tsai PC, Martin TC, Mandaviya PR, Jansen R, Peters MJ, Duijts L, Jaddoe VWV, Tiemeier H, Felix JF, Willemsen G, de Geus EJC, Chu AY, Levy D, Hwang SJ, Bressler J, Gondalia R, Salfati EL, Herder C, Hidalgo BA, Tanaka T, Moore AZ, Lemaitre RN, Jhun MA, Smith JA, Sotoodehnia N, Bandinelli S, Ferrucci L, Arnett DK, Grallert H, Assimes TL, Hou L, Baccarelli A, Whitsel EA, van Dijk KW, Amin N, Uitterlinden AG, Sijbrands EJG, Franco OH, Dehghan A, Spector TD, Dupuis J, Hivert MF, Rotter JI, Meigs JB, Pankow JS, van Meurs JBJ, Isaacs A, Boomsma DI, Bell JT, Demirkan A, van Duijn CM. An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis. Nat Commun. 2019 June;10(1):2581. Epub 2019/06/15. doi: 10.1038/s41467-019-10487-4. (PubMed ID Number: 31197173; PMCID: PMC6565679).

Osazuwa-Peters OL, Schwander K, Waken RJ, de Las Fuentes L, Kilpelainen TO, Loos RJF, Racette SB, Sung YJ, Rao DC. The Promise of Selecting Individuals from the Extremes of Exposure in the Analysis of Gene-Physical Activity Interactions. Hum Hered. 2018;83(6):315-32. Epub 2019/06/06. doi: 10.1159/000499711. (PubMed ID Number: 31167214; PMCID: PMC6662918).

Parker N, Vidal-Pineiro D, French L, Shin J, Adams HHH, Brodaty H, Cox SR, Deary IJ, Fjell AM, Frenzel S, Grabe H, Hosten N, Ikram MA, Jiang J, Knol MJ, Mazoyer B, Mishra A, Sachdev PS, Salum G, Satizabal CL, Schmidt H, Schmidt R, Seshadri S, Schumann G, Volzke H, Walhovd KB, Wen W, Wittfeld K, Yang Q, Debette S, Pausova Z, Paus T. Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan. Cereb Cortex. 2019. Epub 2019/06/27. doi: 10.1093/cercor/bhz108. (PubMed ID Number: 31240317).

Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019 September;138(3):401-13. Epub 2019/06/12. doi: 10.1007/s00401-019-02031-x. (PubMed ID Number: 31183671; PMCID: PMC6689453).

Weinstein G, Davis-Plourde K, Himali JJ, Zelber-Sagi S, Beiser AS, Seshadri S. Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study. Liver Int. 2019 September;39(9):1713-21. Epub 2019/06/04. doi: 10.1111/liv.14161. (PubMed ID Number: 31155826; PMCID: PMC6736704).

Yu B, Zanetti KA, Temprosa M, Albanes D, Appel N, Barrera CB, Ben-Shlomo Y, Boerwinkle E, Casas JP, Clish C, Dale C, Dehghan A, Derkach A, Eliassen AH, Elliott P, Fahy E, Gieger C, Gunter MJ, Harada S, Harris T, Herr DR, Herrington D, Hirschhorn JN, Hoover E, Hsing AW, Johansson M, Kelly RS, Khoo CM, Kivimaki M, Kristal BS, Langenberg C, Lasky-Su J, Lawlor DA, Lotta LA, Mangino M, Le Marchand L, Mathe E, Matthews CE, Menni C, Mucci LA, Murphy R, Oresic M, Orwoll E, Ose J, Pereira AC, Playdon MC, Poston L, Price J, Qi Q, Rexrode K, Risch A, Sampson J, Seow WJ, Sesso HD, Shah SH, Shu XO, Smith GCS, Sovio U, Stevens VL, Stolzenberg-Solomon R, Takebayashi T, Tillin T, Travis R, Tzoulaki I, Ulrich CM, Vasan RS, Verma M, Wang Y, Wareham NJ, Wong A, Younes N, Zhao H, Zheng W, Moore SC. The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. Am J Epidemiol. 2019 June;188(6):991-1012. Epub 2019/06/04. doi: 10.1093/aje/kwz028. (PubMed ID Number: 31155658; PMCID: PMC6545286).

Zheng S, Lubin B, Au R, Murabito JM, Benjamin EJ, Shwartz M. Advantages of Continuous-Valued Risk Scores for Predicting Long-Term Costs: The Framingham Coronary Heart Disease 10-Year Risk Score. Adv Geriatr Med Res. 2019;1(1). doi: 10.20900/agmr20190004. (PubMed ID Number: 31448373; PMCID: PMC6707532).

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July

Antonelli J, Claggett BL, Henglin M, Kim A, Ovsak G, Kim N, Deng K, Rao K, Tyagi O, Watrous JD, Lagerborg KA, Hushcha PV, Demler OV, Mora S, Niiranen TJ, Pereira AC, Jain M, Cheng S. Statistical Workflow for Feature Selection in Human Metabolomics Data. Metabolites. 2019;9(7). Epub 2019/07/25. doi: 10.3390/metabo9070143. (PubMed ID Number: 31336989; PMCID: PMC6680705).

Behnam V, Rong J, Larson MG, Gotal JD, Benjamin EJ, Hamburg NM, Vasan RS, Mitchell GF. Windkessel Measures Derived From Pressure Waveforms Only: The Framingham Heart Study. J Am Heart Assoc. 2019;8(14):e012300. Epub 2019/07/04. doi: 10.1161/jaha.119.012300. (PubMed ID Number: 31266389; PMCID: PMC6662135).

Beunza JJ, Puertas E, Garcia-Ovejero E, Villalba G, Condes E, Koleva G, Hurtado C, Landecho MF. Comparison of machine learning algorithms for clinical event prediction (risk of coronary heart disease). J Biomed Inform. 2019;97:103257. Epub 2019/08/03. doi: 10.1016/j.jbi.2019.103257. (PubMed ID Number: 31374261).

Evangelou E, Gao H, Chu C, Ntritsos G, Blakeley P, Butts AR, Pazoki R, Suzuki H, Koskeridis F, Yiorkas AM, Karaman I, Elliott J, Luo Q, Aeschbacher S, Bartz TM, Baumeister SE, Braund PS, Brown MR, Brody JA, Clarke TK, Dimou N, Faul JD, Homuth G, Jackson AU, Kentistou KA, Joshi PK, Lemaitre RN, Lind PA, Lyytikainen LP, Mangino M, Milaneschi Y, Nelson CP, Nolte IM, Perala MM, Polasek O, Porteous D, Ratliff SM, Smith JA, Stancakova A, Teumer A, Tuominen S, Theriault S, Vangipurapu J, Whitfield JB, Wood A, Yao J, Yu B, Zhao W, Arking DE, Auvinen J, Liu C, Mannikko M, Risch L, Rotter JI, Snieder H, Veijola J, Blakemore AI, Boehnke M, Campbell H, Conen D, Eriksson JG, Grabe HJ, Guo X, van der Harst P, Hartman CA, Hayward C, Heath AC, Jarvelin MR, Kahonen M, Kardia SLR, Kuhne M, Kuusisto J, Laakso M, Lahti J, Lehtimaki T, McIntosh AM, Mohlke KL, Morrison AC, Martin NG, Oldehinkel AJ, Penninx B, Psaty BM, Raitakari OT, Rudan I, Samani NJ, Scott LJ, Spector TD, Verweij N, Weir DR, Wilson JF, Levy D, Tzoulaki I, Bell JD, Matthews PM, Rothenfluh A, Desrivieres S, Schumann G, Elliott P. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nat Hum Behav. 2019. Epub 2019/07/31. doi: 10.1038/s41562-019-0653-z. (PubMed ID Number: 31358974).

Gupta A, Preis SR, Beiser AS, Splansky GL, DeCarli CS, Au R, Driver JA. Relationship of Cancer to Brain Aging Markers of Alzheimer’s Disease: The Framingham Heart Study. Adv Geriatr Med Res. 2019;1. Epub 2019/07/30. doi: 10.20900/agmr20190006. (PubMed ID Number: 31355371; PMCID: PMC6659723).

Harris WS, Jackson KH, Brenna JT, Rodriguez JC, Tintle NL, Cornish L. Survey of the erythrocyte EPA+DHA levels in the heart attack/stroke belt. Prostaglandins Leukot Essent Fatty Acids. 2019;148:30-4. Epub 2019/09/08. doi: 10.1016/j.plefa.2019.07.010. (PubMed ID Number: 31492431).

Henglin M, Niiranen T, Watrous JD, Lagerborg KA, Antonelli J, Claggett BL, Demosthenes EJ, von Jeinsen B, Demler O, Vasan RS, Larson MG, Jain M, Cheng S. A Single Visualization Technique for Displaying Multiple Metabolite-Phenotype Associations. Metabolites. 2019;9(7). Epub 2019/07/05. doi: 10.3390/metabo9070128. (PubMed ID Number: 31269707; PMCID: PMC6680673).

Huan T, Mendelson M, Joehanes R, Yao C, Liu C, Song C, Bhattacharya A, Rong J, Tanriverdi K, Keefe J, Murabito JM, Courchesne P, Larson MG, Freedman JE, Levy D. Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits. Epigenetics. 2019:1-16. Epub 2019/07/10. doi: 10.1080/15592294.2019.1640547. (PubMed ID Number: 31282290).

Liu CT, Merino J, Rybin D, DiCorpo D, Benke KS, Bragg-Gresham JL, Canouil M, Corre T, Grallert H, Isaacs A, Kutalik Z, Lahti J, Marullo L, Marzi C, Rasmussen-Torvik LJ, Rocheleau G, Rueedi R, Scapoli C, Verweij N, Vogelzangs N, Willems SM, Yengo L, Bakker SJL, Beilby J, Hui J, Kajantie E, Muller-Nurasyid M, Rathmann W, Balkau B, Bergmann S, Eriksson JG, Florez JC, Froguel P, Harris T, Hung J, James AL, Kavousi M, Miljkovic I, Musk AW, Palmer LJ, Peters A, Roussel R, van der Harst P, van Duijn CM, Vollenweider P, Barroso I, Prokopenko I, Dupuis J, Meigs JB, Bouatia-Naji N. Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals. Sci Rep. 2019;9(1):9439. Epub 2019/07/03. doi: 10.1038/s41598-019-45823-7. (PubMed ID Number: 31263163; PMCID: PMC6602949).

Naj AC, Lin H, Vardarajan BN, White S, Lancour D, Ma Y, Schmidt M, Sun F, Butkiewicz M, Bush WS, Kunkle BW, Malamon J, Amin N, Choi SH, Hamilton-Nelson KL, van der Lee SJ, Gupta N, Koboldt DC, Saad M, Wang B, Nato AQ, Jr., Sohi HK, Kuzma A, Wang LS, Cupples LA, van Duijn C, Seshadri S, Schellenberg GD, Boerwinkle E, Bis JC, Dupuis J, Salerno WJ, Wijsman EM, Martin ER, DeStefano AL. Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer’s disease sequencing project. Genomics. 2019;111(4):808-18. Epub 2018/06/02. doi: 10.1016/j.ygeno.2018.05.004. (PubMed ID Number: 29857119; PMCID: PMC6397097).

Pase MP, Himali JJ, Aparicio HJ, Romero JR, Satizabal CL, Maillard P, DeCarli C, Beiser AS, Seshadri S. Plasma total-tau as a biomarker of stroke risk in the community. Ann Neurol. 2019;86(3):463-7. Epub 2019/07/05. doi: 10.1002/ana.25542. (PubMed ID Number: 31271449).

Pencina KM, Thanassoulis G, Wilkins JT, Vasan RS, Navar AM, Peterson ED, Pencina MJ, Sniderman AD. Trajectories of Non-HDL Cholesterol Across Midlife: Implications for Cardiovascular Prevention. J Am Coll Cardiol. 2019;74(1):70-9. Epub 2019/07/06. doi: 10.1016/j.jacc.2019.04.047. (PubMed ID Number: 31272554).

Synn AJ, Li W, San Jose Estepar R, Zhang C, Washko GR, O’Connor GT, Araki T, Hatabu H, Bankier AA, Mittleman MA, Rice MB. Radiographic Pulmonary Vessel Volume, Lung Function, and Airways Disease in the Framingham Heart Study. Eur Respir J. 2019. Epub 2019/06/30. doi: 10.1183/13993003.00408-2019. (PubMed ID Number: 31248956).

Vasan RS, Short MI, Niiranen TJ, Xanthakis V, DeCarli C, Cheng S, Seshadri S, Mitchell GF. Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes. J Am Heart Assoc. 2019;8(14):e012141. Epub 2019/07/16. doi: 10.1161/jaha.119.012141. (PubMed ID Number: 31303106; PMCID: PMC6662123).

Wolters FJ, Yang Q, Biggs ML, Jakobsdottir J, Li S, Evans DS, Bis JC, Harris TB, Vasan RS, Zilhao NR, Ghanbari M, Ikram MA, Launer L, Psaty BM, Tranah GJ, Kulminski AM, Gudnason V, Seshadri S. The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE). PLoS ONE. 2019;14(7):e0219668. Epub 2019/07/30. doi: 10.1371/journal.pone.0219668. (PubMed ID Number: 31356640; PMCID: PMC6663005).

Zhang Y, Vittinghoff E, Pletcher MJ, Allen NB, Zeki Al Hazzouri A, Yaffe K, Balte PP, Alonso A, Newman AB, Ives DG, Rana JS, Lloyd-Jones D, Vasan RS, Bibbins-Domingo K, Gooding HC, de Ferranti SD, Oelsner EC, Moran AE. Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events. J Am Coll Cardiol. 2019;74(3):330-41. Epub 2019/07/20. doi: 10.1016/j.jacc.2019.03.529. (PubMed ID Number: 31319915).

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August

Agha G, Mendelson MM, Ward-Caviness CK, Joehanes R, Huan T, Gondalia R, Salfati E, Brody JA, Fiorito G, Bressler J, Chen BH, Ligthart S, Guarrera S, Colicino E, Just AC, Wahl S, Gieger C, Vandiver AR, Tanaka T, Hernandez DG, Pilling LC, Singleton AB, Sacerdote C, Krogh V, Panico S, Tumino R, Li Y, Zhang G, Stewart JD, Floyd JS, Wiggins KL, Rotter JI, Multhaup M, Bakulski K, Horvath S, Tsao PS, Absher DM, Vokonas P, Hirschhorn J, Fallin MD, Liu C, Bandinelli S, Boerwinkle E, Dehghan A, Schwartz JD, Psaty BM, Feinberg AP, Hou L, Ferrucci L, Sotoodehnia N, Matullo G, Peters A, Fornage M, Assimes TL, Whitsel EA, Levy D, Baccarelli AA. Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease. Circulation. 2019;140(8):645-57. Epub 2019/08/20. doi: 10.1161/circulationaha.118.039357. (PubMed ID Number: 31424985).

Bangen KJ, Armstrong NM, Au R, Gross AL. Metabolic Syndrome and Cognitive Trajectories in the Framingham Offspring Study. J Alzheimers Dis. 2019. Epub 2019/08/28. doi: 10.3233/jad-190261. (PubMed ID Number: 31450495).

Brunner KT, Pedley A, Massaro JM, Hoffmann U, Benjamin EJ, Long MT. Increasing Liver Fat Is Associated With Incident Cardiovascular Risk Factors. Clin Gastroenterol Hepatol. 2019. Epub 2019/08/14. doi: 10.1016/j.cgh.2019.08.003. (PubMed ID Number: 31404666).

Conner SC, Lodi S, Lunetta KL, Casas JP, Lubitz SA, Ellinor PT, Anderson CD, Huang Q, Coleman J, White WB, Benjamin EJ, Trinquart L. Refining the Association Between Body Mass Index and Atrial Fibrillation: G-Formula and Restricted Mean Survival Times. J Am Heart Assoc. 2019;8(16):e013011. Epub 2019/08/09. doi: 10.1161/jaha.119.013011. (PubMed ID Number: 31390924).

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppala I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanche H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylha M, Kahonen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimaki T, Lieb W, Lyytikainen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sorensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019;10(1):3669. Epub 2019/08/16. doi: 10.1038/s41467-019-11558-2. (PubMed ID Number: 31413261; PMCID: PMC6694136).

Duncan MS, Freiberg MS, Greevy RA, Jr., Kundu S, Vasan RS, Tindle HA. Association of Smoking Cessation With Subsequent Risk of Cardiovascular Disease. JAMA. 2019;322(7):642-50. Epub 2019/08/21. doi: 10.1001/jama.2019.10298. (PubMed ID Number: 31429895; PMCID: PMC6704757).

Ekelund U, Tarp J, Steene-Johannessen J, Hansen BH, Jefferis B, Fagerland MW, Whincup P, Diaz KM, Hooker SP, Chernofsky A, Larson MG, Spartano N, Vasan RS, Dohrn IM, Hagstromer M, Edwardson C, Yates T, Shiroma E, Anderssen SA, Lee IM. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. BMJ. 2019;366:l4570. Epub 2019/08/23. doi: 10.1136/bmj.l4570. (PubMed ID Number: 31434697; PMCID: PMC6699591).

Koupenova M, Mick E, Corkrey HA, Singh A, Tanriverdi SE, Vitseva O, Levy D, Keeler AM, Ezzaty Mirhashemi M, ElMallah MK, Gerstein M, Rozowsky J, Tanriverdi K, Freedman JE. Pollen-derived RNAs Are Found in the Human Circulation. iScience. 2019;19:916-26. Epub 2019/09/14. doi: 10.1016/j.isci.2019.08.035. (PubMed ID Number: 31518900; PMCID: PMC6742912).

Lee Y, Sun D, Ori APS, Lu AT, Seeboth A, Harris SE, Deary IJ, Marioni RE, Soerensen M, Mengel-From J, Hjelmborg J, Christensen K, Wilson JG, Levy D, Reiner AP, Chen W, Li S, Harris JR, Magnus P, Aviv A, Jugessur A, Horvath S. Epigenome-wide association study of leukocyte telomere length. Aging (Albany NY). 2019;11(16):5876-94. Epub 2019/08/29. doi: 10.18632/aging.102230. (PubMed ID Number: 31461406; PMCID: PMC6738430).

Lu AT, Seeboth A, Tsai PC, Sun D, Quach A, Reiner AP, Kooperberg C, Ferrucci L, Hou L, Baccarelli AA, Li Y, Harris SE, Corley J, Taylor A, Deary IJ, Stewart JD, Whitsel EA, Assimes TL, Chen W, Li S, Mangino M, Bell JT, Wilson JG, Aviv A, Marioni RE, Raj K, Horvath S. DNA methylation-based estimator of telomere length. Aging (Albany NY). 2019;11(16):5895-923. Epub 2019/08/20. doi: 10.18632/aging.102173. (PubMed ID Number: 31422385; PMCID: PMC6738410).

Mandaviya PR, Joehanes R, Brody J, Castillo-Fernandez JE, Dekkers KF, Do AN, Graff M, Hanninen IK, Tanaka T, de Jonge EAL, Kiefte-de Jong JC, Absher DM, Aslibekyan S, de Rijke YB, Fornage M, Hernandez DG, Hurme MA, Ikram MA, Jacques PF, Justice AE, Kiel DP, Lemaitre RN, Mendelson MM, Mikkila V, Moore AZ, Pallister T, Raitakari OT, Schalkwijk CG, Sha J, Slagboom EPE, Smith CE, Stehouwer CDA, Tsai PC, Uitterlinden AG, van der Kallen CJH, van Heemst D, Arnett DK, Bandinelli S, Bell JT, Heijmans BT, Lehtimaki T, Levy D, North KE, Sotoodehnia N, van Greevenbroek MMJ, van Meurs JBJ, Heil SG. Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals. Am J Clin Nutr. 2019;110(2):437-50. Epub 2019/06/06. doi: 10.1093/ajcn/nqz031. (PubMed ID Number: 31165884; PMCID: PMC6669135).

McGrath ER, Himali JJ, Levy D, Conner SC, DeCarli CS, Pase MP, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating IGFBP-2: a novel biomarker for incident dementia. Ann Clin Transl Neurol. 2019. Epub 2019/08/03. doi: 10.1002/acn3.50854. (PubMed ID Number: 31373442).

Murphy AM, Smith CE, Murphy LM, Follis JL, Tanaka T, Richardson K, Noordam R, Lemaitre RN, Kahonen M, Dupuis J, Voortman T, Marouli E, Mook-Kanamori DO, Raitakari OT, Hong J, Dehghan A, Dedoussis G, de Mutsert R, Lehtimaki T, Liu CT, Rivadeneira F, Deloukas P, Mikkila V, Meigs JB, Uitterlinden A, Ikram MA, Franco OH, Hughes M, P OG, Ordovas JM, Roche HM. Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta-Analysis of 19 005 Individuals. Mol Nutr Food Res. 2019:e1900226. Epub 2019/08/23. doi: 10.1002/mnfr.201900226. (PubMed ID Number: 31432628).

Rice MB, Li W, Schwartz J, Di Q, Kloog I, Koutrakis P, Gold DR, Hallowell RW, Zhang C, O’Connor G, Washko GR, Hunninghake GM, Mittleman MA. Ambient air pollution exposure and risk and progression of interstitial lung abnormalities: the Framingham Heart Study. Thorax. 2019. Epub 2019/08/09. doi: 10.1136/thoraxjnl-2018-212877. (PubMed ID Number: 31391318).

Salinas J, Lin H, Aparico HJ, Huan T, Liu C, Rong J, Beiser A, Himali JJ, Freedman JE, Larson MG, Rosand J, Soreq H, Levy D, Seshadri S. Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study. PLoS ONE. 2019;14(8):e0219261. Epub 2019/08/09. doi: 10.1371/journal.pone.0219261. (PubMed ID Number: 31393881; PMCID: PMC6687152).

van der Lee SJ, Knol MJ, Chauhan G, Satizabal CL, Smith AV, Hofer E, Bis JC, Hibar DP, Hilal S, van den Akker EB, Arfanakis K, Bernard M, Yanek LR, Amin N, Crivello F, Cheung JW, Harris TB, Saba Y, Lopez OL, Li S, van der Grond J, Yu L, Paus T, Roshchupkin GV, Amouyel P, Jahanshad N, Taylor KD, Yang Q, Mathias RA, Boehringer S, Mazoyer B, Rice K, Cheng CY, Maillard P, van Heemst D, Wong TY, Niessen WJ, Beiser AS, Beekman M, Zhao W, Nyquist PA, Chen C, Launer LJ, Psaty BM, Ikram MK, Vernooij MW, Schmidt H, Pausova Z, Becker DM, De Jager PL, Thompson PM, van Duijn CM, Bennett DA, Slagboom PE, Schmidt R, Longstreth WT, Ikram MA, Seshadri S, Debette S, Gudnason V, Adams HHH, DeCarli C. A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. Commun Biol. 2019;2:285. Epub 2019/08/10. doi: 10.1038/s42003-019-0537-9. (PubMed ID Number: 31396565; PMCID: PMC6677735).

Zhu H, Tao Q, Ang TFA, Massaro J, Gan Q, Salim S, Zhu RY, Kolachalama VB, Zhang X, Devine S, Auerbach SH, DeCarli C, Au R, Qiu WQ. Association of Plasma Amylin Concentration With Alzheimer Disease and Brain Structure in Older Adults. JAMA Netw Open. 2019;2(8):e199826. Epub 2019/08/23. doi: 10.1001/jamanetworkopen.2019.9826. (PubMed ID Number: 31433485; PMCID: PMC6707010).

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September

Cardona A, Day FR, Perry JRB, Loh M, Chu AY, Lehne B, Paul DS, Lotta LA, Stewart ID, Kerrison ND, Scott RA, Khaw KT, Forouhi NG, Langenberg C, Liu C, Mendelson MM, Levy D, Beck S, Leslie RD, Dupuis J, Meigs JB, Kooner JS, Pihlajamaki J, Vaag A, Perfilyev A, Ling C, Hivert MF, Chambers JC, Wareham NJ, Ong KK. Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study. Diabetes. 2019. Epub 2019/09/12. doi: 10.2337/db18-0290. (PubMed ID Number: 31506343).

Enserro DM, Demler OV, Pencina MJ, D’Agostino RB, Sr. Measures for evaluation of prognostic improvement under multivariate normality for nested and nonnested models. Stat Med. 2019;38(20):3817-31. Epub 2019/06/19. doi: 10.1002/sim.8204. (PubMed ID Number: 31211443).

Geidenstam N, Hsu YH, Astley CM, Mercader JM, Ridderstrale M, Gonzalez ME, Gonzalez C, Hirschhorn JN, Salem RM. Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain. PLoS ONE. 2019;14(9):e0222445. Epub 2019/09/29. doi: 10.1371/journal.pone.0222445. (PubMed ID Number: 31560688).

Georgakis MK, Malik R, Bjorkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt MS, Engstrom G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schiopu A, Soderholm M, Wareham N, Ballantyne CM, Peters A, Seshadri S, Myint PK, Nilsson J, de Lemos JA, Dichgans M. Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals. Circ Res. 2019;125(8):773-82. Epub 2019/09/04. doi: 10.1161/circresaha.119.315380. (PubMed ID Number: 31476962; PMCID: PMC6763364).

Huan T, Joehanes R, Song C, Peng F, Guo Y, Mendelson M, Yao C, Liu C, Ma J, Richard M, Agha G, Guan W, Almli LM, Conneely KN, Keefe J, Hwang SJ, Johnson AD, Fornage M, Liang L, Levy D. Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease. Nat Commun. 2019;10(1):4267. Epub 2019/09/21. doi: 10.1038/s41467-019-12228-z. (PubMed ID Number: 31537805; PMCID: PMC6753136).

Lau ES, Paniagua SM, Guseh JS, Bhambhani V, Zanni MV, Courchesne P, Lyass A, Larson MG, Levy D, Ho JE. Sex Differences in Circulating Biomarkers of Cardiovascular Disease. J Am Coll Cardiol. 2019;74(12):1543-53. Epub 2019/09/21. doi: 10.1016/j.jacc.2019.06.077. (PubMed ID Number: 31537263; PMCID: PMC6756178).

Lin H, Rogers GT, Lunetta KL, Levy D, Miao X, Troy LM, Jacques PF, Murabito JM. Healthy diet is associated with gene expression in blood: the Framingham Heart Study. Am J Clin Nutr. 2019;110(3):742-9. Epub 2019/06/13. doi: 10.1093/ajcn/nqz060. (PubMed ID Number: 31187853; PMCID: PMC6736078).

Nwabuo CC, Duncan M, Xanthakis V, Peterson LR, Mitchell GF, McManus D, Cheng S, Vasan RS. Association of Circulating Ceramides With Cardiac Structure and Function in the Community: The Framingham Heart Study. J Am Heart Assoc. 2019;8(19):e013050. Epub 2019/09/25. doi: 10.1161/jaha.119.013050. (PubMed ID Number: 31549564).

Sarnowski C, Leong A, Raffield LM, Wu P, de Vries PS, DiCorpo D, Guo X, Xu H, Liu Y, Zheng X, Hu Y, Brody JA, Goodarzi MO, Hidalgo BA, Highland HM, Jain D, Liu CT, Naik RP, O’Connell JR, Perry JA, Porneala BC, Selvin E, Wessel J, Psaty BM, Curran JE, Peralta JM, Blangero J, Kooperberg C, Mathias R, Johnson AD, Reiner AP, Mitchell BD, Cupples LA, Vasan RS, Correa A, Morrison AC, Boerwinkle E, Rotter JI, Rich SS, Manning AK, Dupuis J, Meigs JB. Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program. Am J Hum Genet. 2019;105(4):706-18. Epub 2019/10/01. doi: 10.1016/j.ajhg.2019.08.010. (PubMed ID Number: 31564435).

Sikdar S, Joehanes R, Joubert BR, Xu CJ, Vives-Usano M, Rezwan FI, Felix JF, Ward JM, Guan W, Richmond RC, Brody JA, Kupers LK, Baiz N, Haberg SE, Smith JA, Reese SE, Aslibekyan S, Hoyo C, Dhingra R, Markunas CA, Xu T, Reynolds LM, Just AC, Mandaviya PR, Ghantous A, Bennett BD, Wang T, The BC, Bakulski KM, Melen E, Zhao S, Jin J, Herceg Z, Meurs JV, Taylor JA, Baccarelli AA, Murphy SK, Liu Y, Munthe-Kaas MC, Deary IJ, Nystad W, Waldenberger M, Annesi-Maesano I, Conneely K, Jaddoe VW, Arnett D, Snieder H, Kardia SL, Relton CL, Ong KK, Ewart S, Moreno-Macias H, Romieu I, Sotoodehnia N, Fornage M, Motsinger-Reif A, Koppelman GH, Bustamante M, Levy D, London SJ. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics. 2019. Epub 2019/09/20. doi: 10.2217/epi-2019-0066. (PubMed ID Number: 31536415).

Spartano NL, Lin H, Sun F, Lunetta KL, Trinquart L, Valentino M, Manders ES, Pletcher MJ, Marcus GM, McManus DD, Benjamin EJ, Fox CS, Olgin JE, Murabito JM. Comparison of On-Site Versus Remote Mobile Device Support in the Framingham Heart Study Using the Health eHeart Study for Digital Follow-up: Randomized Pilot Study Set Within an Observational Study Design. JMIR Mhealth Uhealth. 2019;7(9):e13238. Epub 2019/10/02. doi: 10.2196/13238. (PubMed ID Number: 31573928).

Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, Giri A, Sieber KB, Qiu C, Kirsten H, Tin A, Chu AY, Bansal N, Feitosa MF, Wang L, Chai JF, Cocca M, Fuchsberger C, Gorski M, Hoppmann A, Horn K, Li M, Marten J, Noce D, Nutile T, Sedaghat S, Sveinbjornsson G, Tayo BO, van der Most PJ, Xu Y, Yu Z, Gerstner L, Arnlov J, Bakker SJL, Baptista D, Biggs ML, Boerwinkle E, Brenner H, Burkhardt R, Carroll RJ, Chee ML, Chee ML, Chen M, Cheng CY, Cook JP, Coresh J, Corre T, Danesh J, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Dittrich K, Divers J, Eckardt KU, Ehret G, Endlich K, Felix JF, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Gansevoort RT, Giedraitis V, Gogele M, Grundner-Culemann F, Gudbjartsson DF, Gudnason V, Hamet P, Harris TB, Hicks AA, Holm H, Foo VHX, Hwang SJ, Ikram MA, Ingelsson E, Jaddoe VWV, Jakobsdottir J, Josyula NS, Jung B, Kahonen M, Khor CC, Kiess W, Koenig W, Korner A, Kovacs P, Kramer H, Kramer BK, Kronenberg F, Lange LA, Langefeld CD, Lee JJ, Lehtimaki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Loeffler M, Lyytikainen LP, Mahajan A, Maranville JC, Mascalzoni D, McMullen B, Meisinger C, Meitinger T, Miliku K, Mook-Kanamori DO, Muller-Nurasyid M, Mychaleckyj JC, Nauck M, Nikus K, Ning B, Noordam R, Connell JO, Olafsson I, Palmer ND, Peters A, Podgornaia AI, Ponte B, Poulain T, Pramstaller PP, Rabelink TJ, Raffield LM, Reilly DF, Rettig R, Rheinberger M, Rice KM, Rivadeneira F, Runz H, Ryan KA, Sabanayagam C, Saum KU, Schottker B, Shaffer CM, Shi Y, Smith AV, Strauch K, Stumvoll M, Sun BB, Szymczak S, Tai ES, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorsteinsdottir U, Tonjes A, Tremblay J, Uitterlinden AG, van der Harst P, Verweij N, Vogelezang S, Volker U, Waldenberger M, Wang C, Wilson OD, Wong C, Wong TY, Yang Q, Yasuda M, Akilesh S, Bochud M, Boger CA, Devuyst O, Edwards TL, Ho K, Morris AP, Parsa A, Pendergrass SA, Psaty BM, Rotter JI, Stefansson K, Wilson JG, Susztak K, Snieder H, Heid IM, Scholz M, Butterworth AS, Hung AM, Pattaro C, Kottgen A. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nat Commun. 2019;10(1):4130. Epub 2019/09/13. doi: 10.1038/s41467-019-11576-0. (PubMed ID Number: 31511532; PMCID: PMC6739370).

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October

Andersson C, Lyass A, Xanthakis V, Larson MG, Mitchell GF, Cheng S, Vasan RS. Risk factor-based subphenotyping of heart failure in the community. PLoS ONE. 2019;14(10):e0222886. Epub 2019/10/16. doi: 10.1371/journal.pone.0222886. (PubMed ID Number: 31613888; PMCID: PMC6793865).

Armstrong NM, Bangen KJ, Au R, Gross AL. Associations Between Midlife but not Late-Life, Elevated Coronary Heart Disease Risk and Lower Cognitive Performance: Results From the Framingham Offspring Study. Am J Epidemiol. 2019. Epub 2019/10/03. doi: 10.1093/aje/kwz210. (PubMed ID Number: 31576397).

Binder N, Balmford J, Schumacher M. A multi-state model based reanalysis of the Framingham Heart Study: Is dementia incidence really declining? Eur J Epidemiol. 2019. Epub 2019/10/16. doi: 10.1007/s10654-019-00567-6. (PubMed ID Number: 31612352).

Groh CA, Vittinghoff E, Benjamin EJ, Dupuis J, Marcus GM. Childhood Tobacco Smoke Exposure and Risk of Atrial Fibrillation in Adulthood. J Am Coll Cardiol. 2019;74(13):1658-64. Epub 2019/09/29. doi: 10.1016/j.jacc.2019.07.060. (PubMed ID Number: 31558248; PMCID: PMC6768078).

Liang J, Cade BE, He KY, Wang H, Lee J, Sofer T, Williams S, Li R, Chen H, Gottlieb DJ, Evans DS, Guo X, Gharib SA, Hale L, Hillman DR, Lutsey PL, Mukherjee S, Ochs-Balcom HM, Palmer LJ, Rhodes J, Purcell S, Patel SR, Saxena R, Stone KL, Tang W, Tranah GJ, Boerwinkle E, Lin X, Liu Y, Psaty BM, Vasan RS, Cho MH, Manichaikul A, Silverman EK, Barr RG, Rich SS, Rotter JI, Wilson JG; NHLBI Trans-Omics for Precision Medicine (TOPMed); TOPMed Sleep Working Group, Redline S, Zhu X. Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level. Am J Hum Genet. 2019 Oct 21. pii: S0002-9297(19)30390-8. doi: 10.1016/j.ajhg.2019.10.002. [Epub ahead of print]. (PubMed ID Number: 31668705).

Malhotra R, Mauer AC, Lino Cardenas CL, Guo X, Yao J, Zhang X, Wunderer F, Smith AV, Wong Q, Pechlivanis S, Hwang SJ, Wang J, Lu L, Nicholson CJ, Shelton G, Buswell MD, Barnes HJ, Sigurslid HH, Slocum C, Rourke CO, Rhee DK, Bagchi A, Nigwekar SU, Buys ES, Campbell CY, Harris T, Budoff M, Criqui MH, Rotter JI, Johnson AD, Song C, Franceschini N, Debette S, Hoffmann U, Kälsch H, Nöthen MM, Sigurdsson S, Freedman BI, Bowden DW, Jöckel KH, Moebus S, Erbel R, Feitosa MF, Gudnason V, Thanassoulis G, Zapol WM, Lindsay ME, Bloch DB, Post WS, O’Donnell CJ. HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. Nat Genet. 2019 Oct 28. doi: 10.1038/s41588-019-0514-8. [Epub ahead of print]. (PubMed ID Number: 31659325).

Mez J, Daneshvar DH, Abdolmohammadi B, Chua AS, Alosco ML, Kiernan PT, Evers L, Marshall L, Martin BM, Palmisano JN, Nowinski CJ, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Huber BR, Stein TD, Goldstein LE, Katz DI, Cantu RC, Au R, Kowall NW, Stern RA, McClean MD, Weuve J, Tripodis Y, McKee AC. Duration of American football play and chronic traumatic encephalopathy. Ann Neurol. 2019. Epub 2019/10/08. doi: 10.1002/ana.25611. (PubMed ID Number: 31589352).

Nagtegaal AP, Broer L, Zilhao NR, Jakobsdottir J, Bishop CE, Brumat M, Christiansen MW, Cocca M, Gao Y, Heard-Costa NL, Evans DS, Pankratz N, Pratt SR, Price TR, Spankovich C, Stimson MR, Valle K, Vuckovic D, Wells H, Eiriksdottir G, Fransen E, Ikram MA, Li CM, Longstreth WT, Jr., Steves C, Van Camp G, Correa A, Cruickshanks KJ, Gasparini P, Girotto G, Kaplan RC, Nalls M, Schweinfurth JM, Seshadri S, Sotoodehnia N, Tranah GJ, Uitterlinden AG, Wilson JG, Gudnason V, Hoffman HJ, Williams FMK, Goedegebure A. Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment. Sci Rep. 2019;9(1):15192. doi: 10.1038/s41598-019-51630-x. (PubMed ID Number: 31645637; PMCID: PMC6811684).

Philibert RA, Dogan MV, Mills JA, Long JD. AHRR Methylation is a Significant Predictor of Mortality Risk in Framingham Heart Study. J Insur Med. 2019. Epub 2019/10/17. doi: 10.17849/insm-48-1-1-11.1. (PubMed ID Number: 31618096).

Rojo C, Zhang Q, Keles S. iFunMed: Integrative functional mediation analysis of GWAS and eQTL studies. Genet Epidemiol. 2019;43(7):742-60. Epub 2019/07/23. doi: 10.1002/gepi.22217. (PubMed ID Number: 31328826).

Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, Scholz M, Sargurupremraj M, Jahanshad N, Roshchupkin GV, Smith AV, Bis JC, Jian X, Luciano M, Hofer E, Teumer A, van der Lee SJ, Yang J, Yanek LR, Lee TV, Li S, Hu Y, Koh JY, Eicher JD, Desrivieres S, Arias-Vasquez A, Chauhan G, Athanasiu L, Renteria ME, Kim S, Hoehn D, Armstrong NJ, Chen Q, Holmes AJ, den Braber A, Kloszewska I, Andersson M, Espeseth T, Grimm O, Abramovic L, Alhusaini S, Milaneschi Y, Papmeyer M, Axelsson T, Ehrlich S, Roiz-Santianez R, Kraemer B, Haberg AK, Jones HJ, Pike GB, Stein DJ, Stevens A, Bralten J, Vernooij MW, Harris TB, Filippi I, Witte AV, Guadalupe T, Wittfeld K, Mosley TH, Becker JT, Doan NT, Hagenaars SP, Saba Y, Cuellar-Partida G, Amin N, Hilal S, Nho K, Mirza-Schreiber N, Arfanakis K, Becker DM, Ames D, Goldman AL, Lee PH, Boomsma DI, Lovestone S, Giddaluru S, Le Hellard S, Mattheisen M, Bohlken MM, Kasperaviciute D, Schmaal L, Lawrie SM, Agartz I, Walton E, Tordesillas-Gutierrez D, Davies GE, Shin J, Ipser JC, Vinke LN, Hoogman M, Jia T, Burkhardt R, Klein M, Crivello F, Janowitz D, Carmichael O, Haukvik UK, Aribisala BS, Schmidt H, Strike LT, Cheng CY, Risacher SL, Putz B, Fleischman DA, Assareh AA, Mattay VS, Buckner RL, Mecocci P, Dale AM, Cichon S, Boks MP, Matarin M, Penninx B, Calhoun VD, Chakravarty MM, Marquand AF, Macare C, Kharabian Masouleh S, Oosterlaan J, Amouyel P, Hegenscheid K, Rotter JI, Schork AJ, Liewald DCM, de Zubicaray GI, Wong TY, Shen L, Samann PG, Brodaty H, Roffman JL, de Geus EJC, Tsolaki M, Erk S, van Eijk KR, Cavalleri GL, van der Wee NJA, McIntosh AM, Gollub RL, Bulayeva KB, Bernard M, Richards JS, Himali JJ, Loeffler M, Rommelse N, Hoffmann W, Westlye LT, Valdes Hernandez MC, Hansell NK, van Erp TGM, Wolf C, Kwok JBJ, Vellas B, Heinz A, Olde Loohuis LM, Delanty N, Ho BC, Ching CRK, Shumskaya E, Singh B, Hofman A, van der Meer D, Homuth G, Psaty BM, Bastin ME, Montgomery GW, Foroud TM, Reppermund S, Hottenga JJ, Simmons A, Meyer-Lindenberg A, Cahn W, Whelan CD, van Donkelaar MMJ, Yang Q, Hosten N, Green RC, Thalamuthu A, Mohnke S, Hulshoff Pol HE, Lin H, Jack CR, Jr., Schofield PR, Muhleisen TW, Maillard P, Potkin SG, Wen W, Fletcher E, Toga AW, Gruber O, Huentelman M, Davey Smith G, Launer LJ, Nyberg L, Jonsson EG, Crespo-Facorro B, Koen N, Greve DN, Uitterlinden AG, Weinberger DR, Steen VM, Fedko IO, Groenewold NA, Niessen WJ, Toro R, Tzourio C, Longstreth WT, Jr., Ikram MK, Smoller JW, van Tol MJ, Sussmann JE, Paus T, Lemaitre H, Schroeter ML, Mazoyer B, Andreassen OA, Holsboer F, Depondt C, Veltman DJ, Turner JA, Pausova Z, Schumann G, van Rooij D, Djurovic S, Deary IJ, McMahon KL, Muller-Myhsok B, Brouwer RM, Soininen H, Pandolfo M, Wassink TH, Cheung JW, Wolfers T, Martinot JL, Zwiers MP, Nauck M, Melle I, Martin NG, Kanai R, Westman E, Kahn RS, Sisodiya SM, White T, Saremi A, van Bokhoven H, Brunner HG, Volzke H, Wright MJ, van ‘t Ent D, Nothen MM, Ophoff RA, Buitelaar JK, Fernandez G, Sachdev PS, Rietschel M, van Haren NEM, Fisher SE, Beiser AS, Francks C, Saykin AJ, Mather KA, Romanczuk-Seiferth N, Hartman CA, DeStefano AL, Heslenfeld DJ, Weiner MW, Walter H, Hoekstra PJ, Nyquist PA, Franke B, Bennett DA, Grabe HJ, Johnson AD, Chen C, van Duijn CM, Lopez OL, Fornage M, Wardlaw JM, Schmidt R, DeCarli C, De Jager PL, Villringer A, Debette S, Gudnason V, Medland SE, Shulman JM, Thompson PM, Seshadri S, Ikram MA. Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet. 2019. Epub 2019/10/23. doi: 10.1038/s41588-019-0511-y. (PubMed ID Number: 31636452).

Spartano NL, Demissie S, Himali JJ, Dukes KA, Murabito JM, Vasan RS, Beiser AS, Seshadri S. Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. Alzheimers Dement (NY). 2019 Oct 15;5:618-626. doi:10.1016/j.trci.2019.08.007. eCollection 2019. (PubMed ID Number: 31660424; PubMed Central PMCID: PMC6807299).

Tin A, Marten J, Halperin Kuhns VL, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, Giri A, Sveinbjornsson G, Li M, Chu AY, Hoppmann A, O’Connor LJ, Prins B, Nutile T, Noce D, Akiyama M, Cocca M, Ghasemi S, van der Most PJ, Horn K, Xu Y, Fuchsberger C, Sedaghat S, Afaq S, Amin N, Arnlov J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boerwinkle E, Bottinger EP, Boutin TS, Brumat M, Burkhardt R, Campana E, Campbell A, Campbell H, Carroll RJ, Catamo E, Chambers JC, Ciullo M, Concas MP, Coresh J, Corre T, Cusi D, Felicita SC, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Delgado G, Demirkan A, Devuyst O, Dittrich K, Eckardt KU, Ehret G, Endlich K, Evans MK, Gansevoort RT, Gasparini P, Giedraitis V, Gieger C, Girotto G, Gogele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hayward C, Hicks AA, Hofer E, Holm H, Huang W, Hutri-Kahonen N, Hwang SJ, Ikram MA, Lewis RM, Ingelsson E, Jakobsdottir J, Jonsdottir I, Jonsson H, Joshi PK, Josyula NS, Jung B, Kahonen M, Kamatani Y, Kanai M, Kerr SM, Kiess W, Kleber ME, Koenig W, Kooner JS, Korner A, Kovacs P, Kramer BK, Kronenberg F, Kubo M, Kuhnel B, La Bianca M, Lange LA, Lehne B, Lehtimaki T, Liu J, Loeffler M, Loos RJF, Lyytikainen LP, Magi R, Mahajan A, Martin NG, Marz W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Metspalu A, Milaneschi Y, O’Donnell CJ, Wilson OD, Gaziano JM, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Muller-Nurasyid M, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O’Connell JR, Olafsson I, Padmanabhan S, Penninx B, Perls T, Peters A, Pirastu M, Pirastu N, Pistis G, Polasek O, Ponte B, Porteous DJ, Poulain T, Preuss MH, Rabelink TJ, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rizzi F, Robino A, Rudan I, Krajcoviechova A, Cifkova R, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Salvi E, Schmidt H, Schmidt R, Shaffer CM, Smith AV, Smith BH, Spracklen CN, Strauch K, Stumvoll M, Sulem P, Tajuddin SM, Teren A, Thiery J, Thio CHL, Thorsteinsdottir U, Toniolo D, Tonjes A, Tremblay J, Uitterlinden AG, Vaccargiu S, van der Harst P, van Duijn CM, Verweij N, Volker U, Vollenweider P, Waeber G, Waldenberger M, Whitfield JB, Wild SH, Wilson JF, Yang Q, Zhang W, Zonderman AB, Bochud M, Wilson JG, Pendergrass SA, Ho K, Parsa A, Pramstaller PP, Psaty BM, Boger CA, Snieder H, Butterworth AS, Okada Y, Edwards TL, Stefansson K, Susztak K, Scholz M, Heid IM, Hung AM, Teumer A, Pattaro C, Woodward OM, Vitart V, Kottgen A. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nat Genet. 2019. Epub 2019/10/04. doi: 10.1038/s41588-019-0504-x. (PubMed ID Number: 31578528).

von Jeinsen B, Short MI, Larson MG, Xanthakis V, McManus DD, Benjamin EJ, Mitchell GF, Aragam J, Cheng S, Vasan RS. Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling. J Am Soc Echocardiogr. 2019. Epub 2019/10/19. doi: 10.1016/j.echo.2019.08.001. (PubMed ID Number: 31624026).

Westerman K, Sebastiani P, Jacques P, Liu S, DeMeo D, Ordovas JM. DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure. Clin Epigenetics. 2019;11(1):142. Epub 2019/10/17. doi: 10.1186/s13148-019-0705-2. (PubMed ID Number: 31615550; PMCID: PMC6792327).

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November

Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD, Jr., O’Connor GT, Ortega VE, Xu H, Fingerlin TE, Bosse Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan K, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019. Epub 2019/11/12. doi: 10.1164/rccm.201905-1017OC. (PubMed ID Number: 31710517).

Andersson C, Lin H, Liu C, Levy D, Mitchell GF, Larson MG, Vasan RS. An Integrated Multi-Omics Approach to Identify Genetic Underpinnings of Heart Failure and its Echocardiographic Precursors: The Framingham Heart Study. Circ Genom Precis Med. 2019. Epub 2019/11/09. doi: 10.1161/circgen.118.002489. (PubMed ID Number: 31703168).

Aparicio HJ, Beiser AS, Seshadri S. Response by Aparicio et al to Letter Regarding Article, "Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study". Stroke. 2019;50(12):e425. Epub 2019/11/07. doi: 10.1161/strokeaha.119.027094. (PubMed ID Number: 31684850).

Conner SC, Pase MP, Carneiro H, Raman MR, McKee AC, Alvarez VE, Walker JM, Satizabal CL, Himali JJ, Stein TD, Beiser A, Seshadri S. Mid-life and late-life vascular risk factor burden and neuropathology in old age. Ann Clin Transl Neurol. 2019. Epub 2019/11/07. doi: 10.1002/acn3.50936. (PubMed ID Number: 31691546).

Di Gioia M, Spreafico R, Springstead JR, Mendelson MM, Joehanes R, Levy D, Zanoni I. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat Immunol. 2019. Epub 2019/11/27. doi: 10.1038/s41590-019-0539-2. (PubMed ID Number: 31768073).

Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Gwen Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guethnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies. Lancet Neurol. 2019. Epub 2019/11/11. doi: 10.1016/s1474-4422(19)30393-x. (PubMed ID Number: 31706889).

Gomez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabon MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC. Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nat Med. 2019;25(11):1739-47. Epub 2019/11/09. doi: 10.1038/s41591-019-0610-4. (PubMed ID Number: 31700183).

Harris WS, Zotor FB. n-3 Fatty acids and risk for fatal coronary disease. Proc Nutr Soc. 2019;78(4):526-31. Epub 2019/03/07. doi: 10.1017/s0029665118002902. (PubMed ID Number: 30837013).

Hulme OL, Khurshid S, Weng LC, Anderson CD, Wang EY, Ashburner JM, Ko D, McManus DD, Benjamin EJ, Ellinor PT, Trinquart L, Lubitz SA. Development and Validation of a Prediction Model for Atrial Fibrillation Using Electronic Health Records. JACC Clin Electrophysiol. 2019;5(11):1331-41. Epub 2019/11/23. doi: 10.1016/j.jacep.2019.07.016. (PubMed ID Number: 31753441; PMCID: PMC6884135).

Joffe S, Sellers DE, Ekunwe L, Antoine-Lavigne D, McGraw S, Levy D, Splansky GL. Preferences for Return of Genetic Results among Participants in the Jackson and Framingham Heart Studies. Circ Genom Precis Med. 2019. Epub 2019/11/23. doi: 10.1161/circgen.119.002632. (PubMed ID Number: 31756304).

Li X, Joehanes R, Hoeschele I, Rich SS, Rotter JI, Levy D, Liu Y, Redline S, Sofer T. Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis. EBioMedicine. 2019. Epub 2019/11/26. doi: 10.1016/j.ebiom.2019.11.020. (PubMed ID Number: 31761615).

Lindstrom S, Wang L, Smith EN, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody JA, Pattee JW, Haessler J, Brumpton BM, Chasman DI, Suchon P, Chen MH, Turman C, Germain M, Wiggins KL, MacDonald J, Braekkan SK, Armasu SM, Pankratz N, Jackson RD, Nielsen JB, Giulianini F, Puurunen MK, Ibrahim M, Heckbert SR, Damrauer SM, Natarajan P, Klarin D, de Vries PS, Sabater-Lleal M, Huffman JE, Bammler TK, Frazer KA, McCauley BM, Taylor K, Pankow JS, Reiner AP, Gabrielsen ME, Deleuze JF, O’Donnell CJ, Kim J, McKnight B, Kraft P, Hansen JB, Rosendaal FR, Heit JA, Psaty BM, Tang W, Kooperberg C, Hveem K, Ridker PM, Morange PE, Johnson AD, Kabrhel C, Tregouet DA, Smith NL. Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism. Blood. 2019;134(19):1645-57. Epub 2019/08/20. doi: 10.1182/blood.2019000435. (PubMed ID Number: 31420334).

Long MT, Massaro JM, Hoffmann U, Benjamin EJ, Naimi TS. Alcohol Use is Associated with Hepatic Steatosis Among Persons with Presumed Non-alcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2019. Epub 2019/11/18. doi: 10.1016/j.cgh.2019.11.022. (PubMed ID Number: 31734449).

Nelson RG, Grams ME, Ballew SH, Sang Y, Azizi F, Chadban SJ, Chaker L, Dunning SC, Fox C, Hirakawa Y, Iseki K, Ix J, Jafar TH, Kottgen A, Naimark DMJ, Ohkubo T, Prescott GJ, Rebholz CM, Sabanayagam C, Sairenchi T, Schottker B, Shibagaki Y, Tonelli M, Zhang L, Gansevoort RT, Matsushita K, Woodward M, Coresh J, Shalev V. Development of Risk Prediction Equations for Incident Chronic Kidney Disease. JAMA. 2019. Epub 2019/11/09. doi: 10.1001/jama.2019.17379. (PubMed ID Number: 31703124).

Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpelainen TO, de Vries PS, Sung YJ, Schwander K, Cade BE, Manning A, Aschard H, Brown MR, Chen H, Franceschini N, Musani SK, Richard M, Vojinovic D, Aslibekyan S, Bartz TM, de Las Fuentes L, Feitosa M, Horimoto AR, Ilkov M, Kho M, Kraja A, Li C, Lim E, Liu Y, Mook-Kanamori DO, Rankinen T, Tajuddin SM, van der Spek A, Wang Z, Marten J, Laville V, Alver M, Evangelou E, Graff ME, He M, Kuhnel B, Lyytikainen LP, Marques-Vidal P, Nolte IM, Palmer ND, Rauramaa R, Shu XO, Snieder H, Weiss S, Wen W, Yanek LR, Adolfo C, Ballantyne C, Bielak L, Biermasz NR, Boerwinkle E, Dimou N, Eiriksdottir G, Gao C, Gharib SA, Gottlieb DJ, Haba-Rubio J, Harris TB, Heikkinen S, Heinzer R, Hixson JE, Homuth G, Ikram MA, Komulainen P, Krieger JE, Lee J, Liu J, Lohman KK, Luik AI, Magi R, Martin LW, Meitinger T, Metspalu A, Milaneschi Y, Nalls MA, O’Connell J, Peters A, Peyser P, Raitakari OT, Reiner AP, Rensen PCN, Rice TK, Rich SS, Roenneberg T, Rotter JI, Schreiner PJ, Shikany J, Sidney SS, Sims M, Sitlani CM, Sofer T, Strauch K, Swertz MA, Taylor KD, Uitterlinden AG, van Duijn CM, Volzke H, Waldenberger M, Wallance RB, van Dijk KW, Yu C, Zonderman AB, Becker DM, Elliott P, Esko T, Gieger C, Grabe HJ, Lakka TA, Lehtimaki T, North KE, Penninx B, Vollenweider P, Wagenknecht LE, Wu T, Xiang YB, Zheng W, Arnett DK, Bouchard C, Evans MK, Gudnason V, Kardia S, Kelly TN, Kritchevsky SB, Loos RJF, Pereira AC, Province M, Psaty BM, Rotimi C, Zhu X, Amin N, Cupples LA, Fornage M, Fox EF, Guo X, Gauderman WJ, Rice K, Kooperberg C, Munroe PB, Liu CT, Morrison AC, Rao DC, van Heemst D, Redline S. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun. 2019;10(1):5121. Epub 2019/11/14. doi: 10.1038/s41467-019-12958-0. (PubMed ID Number: 31719535; PMCID: PMC6851116).

Pei YF, Hu WZ, Yang XL, Wei XT, Feng GJ, Zhang H, Shen H, Tian Q, Deng HW, Zhang L. Two functional variants at 6p21.1 were associated with lean mass. Skelet Muscle. 2019;9(1):28. Epub 2019/11/24. doi: 10.1186/s13395-019-0212-3. (PubMed ID Number: 31757224; PMCID: PMC6874818).

Saez ME, Gonzalez-Perez A, Hernandez-Olasagarre B, Bea A, Moreno-Grau S, de Rojas I, Monte-Rubio G, Orellana A, Valero S, Comella JX, Sanchis D, Ruiz A. Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer’s disease. Sci Rep. 2019;9(1):16665. Epub 2019/11/15. doi: 10.1038/s41598-019-52724-2. (PubMed ID Number: 31723151; PMCID: PMC6853976).

Shen L, Cordero JF, Wang JS, Shen Y, Li S, Liang L, Zou Z, Li C. Association between genetically determined leptin and blood lipids considering alcohol consumption: a Mendelian randomisation study. BMJ Open. 2019;9(11):e026860. Epub 2019/11/09. doi: 10.1136/bmjopen-2018-026860. (PubMed ID Number: 31699712; PMCID: PMC6858149).

Tian X, Browning BL, Browning SR. Estimating the Genome-wide Mutation Rate with Three-Way Identity by Descent. Am J Hum Genet. 2019;105(5):883-93. Epub 2019/10/08. doi: 10.1016/j.ajhg.2019.09.012. (PubMed ID Number: 31587867; PMCID: PMC6848988).

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December

Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019;11:286-90. Epub 2019/04/13. doi: 10.1016/j.dadm.2019.02.003. (PubMed ID Number: 30976649; PMCID: PMC6441785).

Brunner FJ, Waldeyer C, Ojeda F, Salomaa V, Kee F, Sans S, Thorand B, Giampaoli S, Brambilla P, Tunstall-Pedoe H, Moitry M, Iacoviello L, Veronesi G, Grassi G, Mathiesen EB, Soderberg S, Linneberg A, Brenner H, Amouyel P, Ferrieres J, Tamosiunas A, Nikitin YP, Drygas W, Melander O, Jockel KH, Leistner DM, Shaw JE, Panagiotakos DB, Simons LA, Kavousi M, Vasan RS, Dullaart RPF, Wannamethee SG, Riserus U, Shea S, de Lemos JA, Omland T, Kuulasmaa K, Landmesser U, Blankenberg S. Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium. Lancet. 2019;394(10215):2173-83. Epub 2019/12/08. doi: 10.1016/s0140-6736(19)32519-x. (PubMed ID Number: 31810609; PMCID: PMC6913519).

de Las Fuentes L, Sung YJ, Sitlani CM, Avery CL, Bartz TM, Keyser C, Evans DS, Li X, Musani SK, Ruiter R, Smith AV, Sun F, Trompet S, Xu H, Arnett DK, Bis JC, Broeckel U, Busch EL, Chen YI, Correa A, Cummings SR, Floyd JS, Ford I, Guo X, Harris TB, Ikram MA, Lange L, Launer LJ, Reiner AP, Schwander K, Smith NL, Sotoodehnia N, Stewart JD, Stott DJ, Sturmer T, Taylor KD, Uitterlinden A, Vasan RS, Wiggins KL, Cupples LA, Gudnason V, Heckbert SR, Jukema JW, Liu Y, Psaty BM, Rao DC, Rotter JI, Stricker B, Wilson JG, Whitsel EA. Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry. Pharmacogenomics J. 2019. Epub 2019/12/07. doi: 10.1038/s41397-019-0132-y. (PubMed ID Number: 31806883).

Hobbs BD, Putman RK, Araki T, Nishino M, Gudmundsson G, Gudnason V, Eiriksdottir G, Zilhao Nogueira NR, Dupuis J, Xu H, O’Connor GT, Manichaikul A, Nguyen J, Podolanczuk AJ, Madahar P, Rotter JI, Lederer DJ, Barr RG, Rich SS, Ampleford EJ, Ortega VE, Peters SP, O’Neal WK, Newell JD, Jr., Bleecker ER, Meyers DA, Allen RJ, Oldham JM, Ma SF, Noth I, Jenkins RG, Maher TM, Hubbard RB, Wain LV, Fingerlin TE, Schwartz DA, Washko GR, Rosas IO, Silverman EK, Hatabu H, Cho MH, Hunninghake GM. Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019;200(11):1402-13. Epub 2019/07/25. doi: 10.1164/rccm.201903-0511OC. (PubMed ID Number: 31339356; PMCID: PMC6884045).

Joshi PS, Heydari M, Kannan S, Alvin Ang TF, Qin Q, Liu X, Mez J, Devine S, Au R, Kolachalama VB. Temporal association of neuropsychological test performance using unsupervised learning reveals a distinct signature of Alzheimer’s disease status. Alzheimers Dement (N Y). 2019;5:964-73. Epub 2020/01/11. doi: 10.1016/j.trci.2019.11.006. (PubMed ID Number: 31921970; PMCID: PMC6944730).

Kaiser J, Allaire B, Fein PM, Lu D, Adams A, Kiel DP, Jarraya M, Guermazi A, Demissie S, Samelson EJ, Bouxsein ML, Morgan EF. Heterogeneity and Spatial Distribution of Intravertebral Trabecular Bone Mineral Density in the Lumbar Spine Is Associated With Prevalent Vertebral Fracture. J Bone Miner Res. 2019. Epub 2019/12/31. doi: 10.1002/jbmr.3946. (PubMed ID Number: 31886907).

Kowalski MH, Qian H, Hou Z, Rosen JD, Tapia AL, Shan Y, Jain D, Argos M, Arnett DK, Avery C, Barnes KC, Becker LC, Bien SA, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Buyske S, Cai J, Cho MH, Choi SH, Choquet H, Cupples LA, Cushman M, Daya M, de Vries PS, Ellinor PT, Faraday N, Fornage M, Gabriel S, Ganesh SK, Graff M, Gupta N, He J, Heckbert SR, Hidalgo B, Hodonsky CJ, Irvin MR, Johnson AD, Jorgenson E, Kaplan R, Kardia SLR, Kelly TN, Kooperberg C, Lasky-Su JA, Loos RJF, Lubitz SA, Mathias RA, McHugh CP, Montgomery C, Moon JY, Morrison AC, Palmer ND, Pankratz N, Papanicolaou GJ, Peralta JM, Peyser PA, Rich SS, Rotter JI, Silverman EK, Smith JA, Smith NL, Taylor KD, Thornton TA, Tiwari HK, Tracy RP, Wang T, Weiss ST, Weng LC, Wiggins KL, Wilson JG, Yanek LR, Zollner S, North KE, Auer PL, Raffield LM, Reiner AP, Li Y. Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations. PLoS Genet. 2019;15(12):e1008500. Epub 2019/12/24. doi: 10.1371/journal.pgen.1008500. (PubMed ID Number: 31869403; PMCID: PMC6953885).

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Liu L, Pei YF, Liu TL, Hu WZ, Yang XL, Li SC, Hai R, Ran S, Zhao LJ, Shen H, Tian Q, Xiao HM, Zhang K, Deng HW, Zhang L. Identification of a 1p21 independent functional variant for abdominal obesity. Int J Obes (Lond). 2019;43(12):2480-90. Epub 2019/04/05. doi: 10.1038/s41366-019-0350-z. (PubMed ID Number: 30944420; PMCID: PMC6776704).

Pase MP, Himali JJ, Beiser AS, DeCarli C, McGrath ER, Satizabal CL, Aparicio HJ, Adams HHH, Reiner AP, Longstreth WT, Jr., Fornage M, Tracy RP, Lopez O, Psaty BM, Levy D, Seshadri S, Bis JC. Association of CD14 with incident dementia and markers of brain aging and injury. Neurology. 2020;94(3):e254-e66. Epub 2019/12/11. doi: 10.1212/wnl.0000000000008682. (PubMed ID Number: 31818907).

Raffield LM, Iyengar AK, Wang B, Gaynor SM, Spracklen CN, Zhong X, Kowalski MH, Salimi S, Polfus LM, Benjamin EJ, Bis JC, Bowler R, Cade BE, Choi WJ, Comellas AP, Correa A, Cruz P, Doddapaneni H, Durda P, Gogarten SM, Jain D, Kim RW, Kral BG, Lange LA, Larson MG, Laurie C, Lee J, Lee S, Lewis JP, Metcalf GA, Mitchell BD, Momin Z, Muzny DM, Pankratz N, Park CJ, Rich SS, Rotter JI, Ryan K, Seo D, Tracy RP, Viaud-Martinez KA, Yanek LR, Zhao LP, Lin X, Li B, Li Y, Dupuis J, Reiner AP, Mohlke KL, Auer PL. Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts. Am J Hum Genet. 2020;106(1):112-20. Epub 2019/12/31. doi: 10.1016/j.ajhg.2019.12.002. (PubMed ID Number: 31883642).

Shen L, Cordero JF, Wang JS, Shen Y, Zhang R, Qi Y, Li C. The effect of leptin on blood pressure considering smoking status: a Mendelian randomization study. Hypertens Res. 2019. Epub 2019/12/14. doi: 10.1038/s41440-019-0376-6. (PubMed ID Number: 31831886).

Smith EE, Biessels GJ, De Guio F, de Leeuw FE, Duchesne S, During M, Frayne R, Ikram MA, Jouvent E, MacIntosh BJ, Thrippleton MJ, Vernooij MW, Adams H, Backes WH, Ballerini L, Black SE, Chen C, Corriveau R, DeCarli C, Greenberg SM, Gurol ME, Ingrisch M, Job D, Lam BYK, Launer LJ, Linn J, McCreary CR, Mok VCT, Pantoni L, Pike GB, Ramirez J, Reijmer YD, Romero JR, Ropele S, Rost NS, Sachdev PS, Scott CJM, Seshadri S, Sharma M, Sourbron S, Steketee RME, Swartz RH, van Oostenbrugge R, van Osch M, van Rooden S, Viswanathan A, Werring D, Dichgans M, Wardlaw JM. Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. Alzheimers Dement (Amst). 2019;11:191-204. Epub 2019/03/13. doi: 10.1016/j.dadm.2019.01.002. (PubMed ID Number: 30859119; PMCID: PMC6396326).

Volgman AS, Bairey Merz CN, Benjamin EJ, Curtis AB, Fang MC, Lindley KJ, Pepine CJ, Vaseghi M, Waldo AL, Wenger NK, Russo AM. Sex and Race/Ethnicity Differences in Atrial Fibrillation. J Am Coll Cardiol. 2019;74(22):2812-5. Epub 2019/11/30. doi: 10.1016/j.jacc.2019.09.045. (PubMed ID Number: 31779796).

Walker ME, Xanthakis V, Moore LL, Vasan RS, Jacques PF. Cumulative sugar-sweetened beverage consumption is associated with higher concentrations of circulating ceramides in the Framingham Offspring Cohort. Am J Clin Nutr. 2019. Epub 2019/12/12. doi: 10.1093/ajcn/nqz257. (PubMed ID Number: 31826243).

Wang B, Lunetta K, Dupuis J, Lubitz SA, Trinquart L, Yao L, Ellinor PT, Benjamin EJ, Lin H. Integrative Omics Approach to Identifying Genes Associated with Atrial Fibrillation. Circ Res. 2019. Epub 2019/12/06. doi: 10.1161/circresaha.119.315179. (PubMed ID Number: 31801406).

Weaver NA, Zhao L, Biesbroek JM, Kuijf HJ, Aben HP, Bae HJ, Caballero MAA, Chappell FM, Chen C, Dichgans M, Duering M, Georgakis MK, van der Giessen RS, Gyanwali B, Hamilton OKL, Hilal S, Vom Hofe EM, de Kort PLM, Koudstaal PJ, Lam BYK, Lim JS, Makin SDJ, Mok VCT, Shi L, Valdes Hernandez MC, Venketasubramanian N, Wardlaw JM, Wollenweber FA, Wong A, Xin X, Biessels GJ. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimers Dement (Amst). 2019;11:310-26. Epub 2019/04/24. doi: 10.1016/j.dadm.2019.02.007. (PubMed ID Number: 31011619; PMCID: PMC6465616).

Weinstein G, Davis-Plourde KL, Beiser AS, Seshadri S. Author response: Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study. Liver Int. 2019. Epub 2019/12/19. doi: 10.1111/liv.14318. (PubMed ID Number: 31850659).

Yin X, Willinger CM, Keefe J, Liu J, Fernandez-Ortiz A, Ibanez B, Penalvo J, Adourian A, Chen G, Corella D, Pamplona R, Portero-Otin M, Jove M, Courchesne P, van Duijn CM, Fuster V, Ordovas JM, Demirkan A, Larson MG, Levy D. Lipidomic profiling identifies signatures of metabolic risk. EBioMedicine. 2019;51:102520. Epub 2019/12/27. doi: 10.1016/j.ebiom.2019.10.046. (PubMed ID Number: 31877415; PMCID: PMC6938899).

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